{"id":"W2129183636","doi":"10.1038/nchembio776","title":"Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A","year":2006,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":364,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Cancer Institute","keywords":"eIF4A; Helicase; RNA Helicase A; Eukaryotic initiation factor; RNA; Internal ribosome entry site; Initiation factor; Biology; Eukaryotic translation; Translation (biology); Cell biology; Messenger RNA; EIF4A1; Ribosome; Genetics; Biochemistry; Computational biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007786896,0.00009568396,0.0001302625,0.00001452217,0.00002353935,0.000002466679,0.0001676398,0.0005581212,0.00003616322],"category_scores_gemma":[0.00009304145,0.00006541811,0.00007708769,0.00006747984,0.0001296617,0.000002568009,0.00006311889,0.0001190377,9.555058e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004895147,"about_ca_system_score_gemma":0.00002545039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009192529,"about_ca_topic_score_gemma":0.000001644889,"domain_scores_codex":[0.9993514,0.00006279777,0.0001885543,0.0002096691,0.00007389743,0.0001137096],"domain_scores_gemma":[0.9995143,0.00001574639,0.0001321406,0.000224013,0.00008799901,0.00002576166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009285674,0.00008013768,0.0005024681,0.000009381632,0.00001063826,8.32399e-8,0.000001612777,2.092055e-7,0.9968129,0.0004367756,0.0008702573,0.001182712],"study_design_scores_gemma":[0.0001757988,0.00008937433,0.0007313746,0.000006363848,0.000007678909,0.000003983183,0.000001631517,0.000002037753,0.9885768,0.0004041336,0.009928918,0.00007185461],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983751,0.0004232363,0.0003635488,0.000228433,0.0001705147,0.0001008364,0.000187099,0.000005009218,0.0001462046],"genre_scores_gemma":[0.9982228,0.00001977255,0.0001415526,0.0001906875,0.0003338881,0.00001073639,0.0009482094,0.000008801829,0.0001235585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009058662,"threshold_uncertainty_score":0.4304742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004974926840147415,"score_gpt":0.2206158351068566,"score_spread":0.2156409082667092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}