{"id":"W2129208532","doi":"10.1128/mcb.06603-11","title":"Klotho Coreceptors Inhibit Signaling by Paracrine Fibroblast Growth Factor 8 Subfamily Ligands","year":2012,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Fibroblast Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of Dental and Craniofacial Research; National Institute of Neurological Disorders and Stroke; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Aging","keywords":"Fibroblast growth factor receptor; Biology; Klotho; Fibroblast growth factor; Fibroblast growth factor receptor 1; FGF19; Subfamily; Paracrine signalling; Cell biology; Tyrosine kinase; Fibroblast growth factor receptor 4; Receptor tyrosine kinase; Receptor; Signal transduction; Biochemistry; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000274649,0.000345249,0.0003129363,0.0001341948,0.00008068887,0.00003033041,0.0002358823,0.0003924268,0.00007293553],"category_scores_gemma":[0.0001024329,0.0003292523,0.000118178,0.0001982977,0.0002335354,0.00001242448,0.0002708573,0.0002656651,0.00002969235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002496772,"about_ca_system_score_gemma":0.00003987751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007138358,"about_ca_topic_score_gemma":0.000007212,"domain_scores_codex":[0.9978542,0.0001783561,0.0003396942,0.000571934,0.0001534413,0.0009024038],"domain_scores_gemma":[0.9992159,0.00002554894,0.0000794668,0.0003104289,0.00006526476,0.0003034081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000695384,0.00009514722,0.05620789,0.00003957652,0.00004290703,0.000007496074,0.00006235336,0.000002107326,0.9426381,0.0002189201,0.0003287454,0.000287214],"study_design_scores_gemma":[0.0007158137,0.0004474832,0.001697902,0.00002157814,0.000008570491,0.00001740263,0.00004749461,0.00001166881,0.9925485,0.00007219782,0.004027439,0.0003839869],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912029,0.004620263,0.003325935,0.00008405847,0.0001139778,0.0002560034,0.00006636524,0.00002185532,0.0003086771],"genre_scores_gemma":[0.9984621,0.0001334637,0.0002318495,0.000208089,0.0001427321,0.00003138093,0.0005591178,0.00006032647,0.0001709231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05450999,"threshold_uncertainty_score":0.999916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008562089143263991,"score_gpt":0.2411718788307478,"score_spread":0.2326097896874838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}