{"id":"W2129208532","doi":"10.1128/mcb.06603-11","title":"Klotho Coreceptors Inhibit Signaling by Paracrine Fibroblast Growth Factor 8 Subfamily Ligands","year":2012,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Fibroblast Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of Dental and Craniofacial Research; National Institute of Neurological Disorders and Stroke; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Aging","keywords":"Fibroblast growth factor receptor; Biology; Klotho; Fibroblast growth factor; Fibroblast growth factor receptor 1; FGF19; Subfamily; Paracrine signalling; Cell biology; Tyrosine kinase; Fibroblast growth factor receptor 4; Receptor tyrosine kinase; Receptor; Signal transduction; Biochemistry; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001609347,0.0002802147,0.0002699518,0.0001599481,0.0001298702,0.0003533916,0.0001937265,0.0001748857,0.001121009],"category_scores_gemma":[0.0002981244,0.0001305611,0.0001932091,0.00006545821,0.0002098993,0.000194642,0.0003554013,0.00038109,0.000315801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003500499,"about_ca_system_score_gemma":0.0003515473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001133905,"about_ca_topic_score_gemma":0.002454514,"domain_scores_codex":[0.9995984,0.00006164974,0.00002086168,0.00003055944,0.000114928,0.0001736466],"domain_scores_gemma":[0.9998302,0.00005032335,0.0000351124,0.00001380848,0.00002414743,0.00004624356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001314433,0.00002278703,0.0005485939,0.00003666967,0.000003900744,0.00007065654,0.00002165075,0.00007283203,0.9962596,0.0002967733,0.00005991382,0.002475152],"study_design_scores_gemma":[0.0000456667,0.0005126452,0.01445922,0.000012632,0.0000209764,0.0007707987,0.00009287646,0.001801749,0.9771718,0.0001903643,0.004913996,0.000007214057],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942141,0.00205092,0.001172016,0.00006439324,0.00001401207,0.00002025232,0.00004391899,0.00003040996,0.00239008],"genre_scores_gemma":[0.9970145,0.0007510583,0.0008838783,0.00005325986,0.000008817398,0.00001872299,0.00007606399,0.000008828774,0.00118488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001133905,"threshold_uncertainty_score":0.003750145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008562089143263991,"score_gpt":0.2411718788307478,"score_spread":0.2326097896874838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}