{"id":"W2129246977","doi":"10.1161/circresaha.114.304800","title":"Gene Therapy for Hypercholesterolemia","year":2014,"lang":"en","type":"letter","venue":"Circulation Research","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"Familial hypercholesterolemia; Medicine; Cholesterol; Allele; Genetic enhancement; LDL receptor; Gerontology; Internal medicine; Genetics; Gene; Lipoprotein; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001431639,0.0006956026,0.001305033,0.0006025835,0.002837498,0.002086005,0.0008923031,0.03328724,0.005446381],"category_scores_gemma":[0.009366941,0.0004553341,0.001086118,0.0003988569,0.00198926,0.001234076,0.0009648307,0.0228997,0.003471456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00330211,"about_ca_system_score_gemma":0.00200791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00232355,"about_ca_topic_score_gemma":0.00470529,"domain_scores_codex":[0.9989611,0.0003337204,0.0000982834,0.0001012036,0.0003484861,0.0001572411],"domain_scores_gemma":[0.998234,0.001114118,0.0001175859,0.0000569651,0.0001921599,0.0002851441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000198362,0.0001661865,0.0009144443,0.00008407421,0.00003889831,0.004368996,0.0001241457,0.0001560673,0.0009362106,0.007508084,0.9514973,0.03400731],"study_design_scores_gemma":[0.0006338738,0.0003818423,0.001468441,0.0003482171,0.0001069387,0.004361656,0.0002126349,0.0009946153,0.001499685,0.01724591,0.9726878,0.00005834381],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.001313574,0.003457737,0.0002484266,0.9699422,0.01808924,0.00002641452,0.00003676495,0.00004536819,0.006840286],"genre_scores_gemma":[0.01415963,0.004505145,0.0005911249,0.9089642,0.05023586,0.0001322661,0.00004858481,0.00003110935,0.02133203],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.03328724,"threshold_uncertainty_score":0.02395862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1697487414301614,"score_gpt":0.4093148572630959,"score_spread":0.2395661158329346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}