{"id":"W2129246977","doi":"10.1161/circresaha.114.304800","title":"Gene Therapy for Hypercholesterolemia","year":2014,"lang":"en","type":"letter","venue":"Circulation Research","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"Familial hypercholesterolemia; Medicine; Cholesterol; Allele; Genetic enhancement; LDL receptor; Gerontology; Internal medicine; Genetics; Gene; Lipoprotein; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003095511,0.0002053129,0.0005419221,0.000409032,0.0002350346,0.00008472418,0.0001855236,0.0009516099,0.0001099346],"category_scores_gemma":[0.000198743,0.0001748257,0.0004667014,0.0002655885,0.0001026186,0.0000424036,0.00003148266,0.002020281,0.000159065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002582538,"about_ca_system_score_gemma":0.0004873212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001255201,"about_ca_topic_score_gemma":0.000001621127,"domain_scores_codex":[0.9962702,0.0004385293,0.0003232253,0.0005999569,0.001692471,0.0006755813],"domain_scores_gemma":[0.9973876,0.0002280543,0.00006385263,0.001215318,0.0009668925,0.0001382545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008396155,0.00003190992,0.0007572498,0.0008781105,0.0002295043,0.00006202543,0.00005294419,0.00001581644,0.0008340779,0.00001605962,0.9334374,0.06360094],"study_design_scores_gemma":[0.001916676,0.0002363483,0.00933918,0.0001200469,0.00003579601,0.0001041359,0.000005798374,0.0003312805,0.0002864911,0.0003286569,0.9871296,0.0001660429],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.03880915,0.002723981,0.004506481,0.9439065,0.0003578422,0.006539415,0.00003412607,0.0001264182,0.002996033],"genre_scores_gemma":[0.1196528,0.0006530761,0.0008933301,0.8368767,0.0328167,0.001634685,0.002859975,0.0002719449,0.004340803],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1070298,"threshold_uncertainty_score":0.8777228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1697487414301614,"score_gpt":0.4093148572630959,"score_spread":0.2395661158329346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}