{"id":"W2129257749","doi":"10.1136/annrheumdis-2013-204741","title":"Ustekinumab, an anti-IL-12/23 p40 monoclonal antibody, inhibits radiographic progression in patients with active psoriatic arthritis: results of an integrated analysis of radiographic data from the phase 3, multicentre, randomised, double-blind, placebo-controlled PSUMMIT-1 and PSUMMIT-2 trials","year":2014,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":298,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Janssen Biotech; Alexion Pharmaceuticals","keywords":"Medicine; Ustekinumab; Psoriatic arthritis; Placebo; Internal medicine; Psoriasis; Methotrexate; Gastroenterology; Rheumatoid arthritis; Surgery; Adalimumab; Dermatology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001854114,0.0005097897,0.003310226,0.0007749607,0.0001835372,0.00005243585,0.0006616337,0.0001233318,0.00002083176],"category_scores_gemma":[0.002912533,0.0002624652,0.0006356676,0.001725639,0.0006060665,0.0004582074,0.000207784,0.0001881514,4.301104e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001375363,"about_ca_system_score_gemma":0.0001189104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001220077,"about_ca_topic_score_gemma":0.001331856,"domain_scores_codex":[0.9940732,0.001722016,0.002092748,0.0007329358,0.0009701895,0.0004089851],"domain_scores_gemma":[0.9928648,0.002106816,0.002287749,0.001992748,0.0004760363,0.0002718719],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6621682,0.008864092,0.2292464,0.0001694088,0.01620924,0.000008373072,0.001060407,0.0001548513,0.00003613268,0.00001092393,0.0001044096,0.08196757],"study_design_scores_gemma":[0.5711495,0.001825952,0.4055603,0.003607069,0.009588721,0.000001040886,0.000835863,0.006716003,0.0004084978,0.00006080072,0.000006359654,0.0002399809],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849441,0.004254582,0.00001692558,0.0001933674,0.00009621539,0.005278141,0.00518014,0.00002373228,0.00001276735],"genre_scores_gemma":[0.9917555,0.003360661,0.0002512027,0.00003989014,0.00002985984,0.0001568728,0.004368233,0.00003513693,0.000002634813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1763139,"threshold_uncertainty_score":0.9999828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05476146153236468,"score_gpt":0.3588714938408338,"score_spread":0.3041100323084692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}