{"id":"W2129257749","doi":"10.1136/annrheumdis-2013-204741","title":"Ustekinumab, an anti-IL-12/23 p40 monoclonal antibody, inhibits radiographic progression in patients with active psoriatic arthritis: results of an integrated analysis of radiographic data from the phase 3, multicentre, randomised, double-blind, placebo-controlled PSUMMIT-1 and PSUMMIT-2 trials","year":2014,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":298,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Janssen Biotech; Alexion Pharmaceuticals","keywords":"Medicine; Ustekinumab; Psoriatic arthritis; Placebo; Internal medicine; Psoriasis; Methotrexate; Gastroenterology; Rheumatoid arthritis; Surgery; Adalimumab; Dermatology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00813778,0.001496459,0.003840152,0.0007777201,0.0004013425,0.0009968275,0.0008881858,0.001083365,0.002818391],"category_scores_gemma":[0.003272359,0.0006906178,0.003022182,0.000982988,0.0008381263,0.0009476299,0.0005378448,0.002140862,0.0003709506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007372058,"about_ca_system_score_gemma":0.001429546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007487547,"about_ca_topic_score_gemma":0.003901042,"domain_scores_codex":[0.9964037,0.002378067,0.0002923988,0.0002854228,0.0004301695,0.0002101333],"domain_scores_gemma":[0.997154,0.0007689639,0.001136793,0.0001718439,0.0002750146,0.000493322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8724711,0.008180769,0.005366464,0.003395303,0.009167105,0.0000584661,0.000156226,0.0006699417,0.008735582,0.00007609972,0.0008939573,0.09082891],"study_design_scores_gemma":[0.755486,0.2043877,0.02807659,0.0002259245,0.007406795,0.0001394226,0.00005233457,0.0004797663,0.001691918,0.0001112688,0.001908657,0.00003358797],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9320157,0.05975292,0.001172574,0.0005653528,0.0002230243,0.003280881,0.001498224,0.0001009422,0.001390323],"genre_scores_gemma":[0.9791387,0.01401624,0.001934208,0.0005524707,0.000412181,0.00176028,0.001331873,0.00001669151,0.0008373286],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00813778,"threshold_uncertainty_score":0.04303718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05476146153236468,"score_gpt":0.3588714938408338,"score_spread":0.3041100323084692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}