{"id":"W2129298171","doi":"10.1371/journal.pone.0005846","title":"Aging and Replicative Senescence Have Related Effects on Human Stem and Progenitor Cells","year":2009,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":479,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Deutsche Krebshilfe; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; Stem Cell Network; Deutsches Krebsforschungszentrum","keywords":"Telomere; Senescence; Biology; Stem cell; Stem cell theory of aging; Progenitor cell; Mesenchymal stem cell; Haematopoiesis; Telomerase; DNA methylation; Somatic cell; Cell biology; Gene expression; Phenotype; Gene; Genetics; Stem cell factor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002074206,0.0001562175,0.0001409191,0.0003745702,0.0001227171,0.0001797241,0.0000512361,0.00011196,0.0009312978],"category_scores_gemma":[0.0002280281,0.00007232783,0.0002016407,0.0003341817,0.0001643853,0.0001039287,0.0001618585,0.0001640172,0.0002052667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009104925,"about_ca_system_score_gemma":0.0001127089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003083422,"about_ca_topic_score_gemma":0.0003663857,"domain_scores_codex":[0.9998622,0.00003007271,0.00001391446,0.00002590457,0.00004321868,0.00002456032],"domain_scores_gemma":[0.9998333,0.00004573145,0.00004765897,0.00002063749,0.00002881036,0.00002377096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002522978,0.00002354024,0.007878075,0.00007449094,0.00001656558,0.0001129871,0.0001496542,0.0000732204,0.984338,0.0001111653,0.00003772552,0.006932369],"study_design_scores_gemma":[0.00001225328,0.001346789,0.3949299,0.00002918598,0.00007603029,0.00164683,0.0002794913,0.0004335194,0.593306,0.0002942375,0.007629094,0.00001668573],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912744,0.00610446,0.001185021,0.00003548893,0.00001182122,0.00001804623,0.0004235542,0.00001104992,0.0009362918],"genre_scores_gemma":[0.9923611,0.003652602,0.001414115,0.00008270115,0.00002193085,0.00003764207,0.001123299,0.000006568892,0.001300154],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009312978,"threshold_uncertainty_score":0.003115475,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04196245092582208,"score_gpt":0.26994616748949,"score_spread":0.2279837165636679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}