{"id":"W2129319352","doi":"10.18433/j3688m","title":"Pharmacokinetics of mirodenafil, a new erectogenic, and its metabolite, SK3541, in rats: involvement of CYP1A1/2, 2B1/2, 2D subfamily, and 3A1/2 for the metabolism of both mirodenafil and SK3541","year":2010,"lang":"en","type":"article","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Metabolite; Pharmacokinetics; Pharmacology; Subfamily; Active metabolite; Medicine; Chemistry; Internal medicine; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001600691,0.0004613586,0.0003989489,0.0003456821,0.0002152556,0.0002594141,0.0001459622,0.000313655,0.001418386],"category_scores_gemma":[0.0001980486,0.0003941006,0.0003728248,0.0001946982,0.0002852741,0.0005391941,0.00008801021,0.0005722604,0.000274831],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003699246,"about_ca_system_score_gemma":0.0003203435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000823201,"about_ca_topic_score_gemma":0.001058092,"domain_scores_codex":[0.9998901,0.00002288604,0.000006226979,0.00002832006,0.00002642868,0.0000260808],"domain_scores_gemma":[0.9998254,0.00001929888,0.00005352863,0.00002612247,0.00002030412,0.00005541341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02729742,0.001323402,0.01057225,0.0001502329,0.0001268891,0.0002463647,0.0001124023,0.0005095413,0.9395235,0.0002748596,0.000244119,0.01961905],"study_design_scores_gemma":[0.0007932587,0.0233168,0.09140243,0.00002079096,0.0004922388,0.001078381,0.0001901605,0.004464655,0.8737534,0.0001954929,0.00424211,0.00005023585],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971379,0.0012553,0.0009926816,0.00005757308,0.00001477308,0.00001517088,0.0001968287,0.00003889186,0.0002908423],"genre_scores_gemma":[0.9939219,0.001503697,0.001424941,0.00007322005,0.00003461531,0.00003878702,0.0006263159,0.00002135962,0.002355271],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001418386,"threshold_uncertainty_score":0.004744947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1511030043438689,"score_gpt":0.4599331404346859,"score_spread":0.3088301360908171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}