{"id":"W2129321855","doi":"10.1073/pnas.0810611105","title":"Ubiquitin signals autophagic degradation of cytosolic proteins and peroxisomes","year":2008,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":528,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Autophagy; Ubiquitin; Cell biology; ATG12; Lysosome; Autophagosome; Cytosol; Cytoplasm; Biology; Protein degradation; Ubiquitin ligase; Ubiquitin-Protein Ligases; Phosphatidylinositol; F-box protein; Biochemistry; Kinase; ATG5; Enzyme; Apoptosis; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002011976,0.0003520724,0.0002914737,0.0003123998,0.0003211612,0.0005162691,0.0001233867,0.0003685631,0.002517723],"category_scores_gemma":[0.0002230324,0.0001721961,0.0002037698,0.0002029011,0.000247141,0.0003591984,0.0004894695,0.0003465241,0.001202807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005207924,"about_ca_system_score_gemma":0.0001859378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002675035,"about_ca_topic_score_gemma":0.0005709526,"domain_scores_codex":[0.9997833,0.00003503977,0.00001412476,0.00004074162,0.00006656556,0.00006009507],"domain_scores_gemma":[0.9998995,0.00001191159,0.00001974884,0.00001256616,0.00002050781,0.00003574409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005708653,0.00004637987,0.000551557,0.0001829775,0.0000178165,0.000529815,0.00003555485,0.00007884367,0.9821899,0.001605368,0.001340829,0.01285003],"study_design_scores_gemma":[0.00005067186,0.0002310546,0.008576681,0.0000278215,0.00002183068,0.001565614,0.0000705436,0.0009211185,0.9659545,0.0007134561,0.02185427,0.00001241997],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9424707,0.03633222,0.006660971,0.0007525569,0.0003453903,0.00005169654,0.0008654949,0.0004914216,0.01202954],"genre_scores_gemma":[0.9759493,0.007006241,0.002157369,0.0001797316,0.00005965976,0.00002380925,0.0007391407,0.00003095557,0.01385384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002517723,"threshold_uncertainty_score":0.008422673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05576985694752111,"score_gpt":0.3185374061451257,"score_spread":0.2627675491976046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}