{"id":"W2129327998","doi":"10.1186/1742-6405-10-15","title":"Mutations in variable domains of the HIV-1 envelope gene can have a significant impact on maraviroc and vicriviroc resistance","year":2013,"lang":"en","type":"article","venue":"AIDS Research and Therapy","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôtel-Dieu de Montréal; Institut National de Santé Publique du Québec; Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"National Institutes of Health; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"Maraviroc; Medicine; Human immunodeficiency virus (HIV); CCR5 receptor antagonist; Virology; Gene; Envelope (radar); Genetics; Immunology; Biology; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004982366,0.0001280183,0.0001961752,0.0001904087,0.0002784577,0.00003632318,0.0001856748,0.00009290559,0.0003968536],"category_scores_gemma":[0.00006573255,0.00007207556,0.00003403871,0.0002916226,0.0006427333,0.00005620733,0.00007085619,0.0003644365,0.00009150476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006206519,"about_ca_system_score_gemma":0.0001779438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002093658,"about_ca_topic_score_gemma":0.0002802724,"domain_scores_codex":[0.9984088,0.0005289605,0.0001705113,0.0002616674,0.0001155492,0.0005145434],"domain_scores_gemma":[0.9990039,0.0004860769,0.00003270392,0.0002997759,0.0001094579,0.00006809649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001474656,0.0009044487,0.189034,0.00003029036,0.0004945688,0.00002220991,0.002200026,0.00000516121,0.7713118,0.002777851,0.00385831,0.02788669],"study_design_scores_gemma":[0.005186819,0.002493033,0.8691854,0.0000801618,0.00000555578,0.00001423605,0.0007553815,0.000003457302,0.1000338,0.01239206,0.009664049,0.0001859864],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934252,0.002942554,0.00001301241,0.001032607,0.0000145911,0.0007440858,0.0002905749,0.000006048682,0.001531317],"genre_scores_gemma":[0.9918857,0.00272166,0.0001247963,0.00003986427,0.000007480728,0.0001808579,0.00006963754,0.00001117762,0.004958866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6801514,"threshold_uncertainty_score":0.4345268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02502237051826484,"score_gpt":0.3095108355155825,"score_spread":0.2844884649973177,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}