{"id":"W2129331946","doi":"10.1200/jco.2012.48.5052","title":"Subgroup-Specific Prognostic Implications of <i>TP53</i> Mutation in Medulloblastoma","year":2013,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":488,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juravinski Cancer Centre","funders":"University of California, Los Angeles; Hospices Civils de Lyon; Masarykova Univerzita; Erasmus Medisch Centrum; University of Ulsan; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Seoul National University; Brain Tumour Charity; Chonnam National University; Université de Lyon; Semmelweis Egyetem; Newcastle University; Debreceni Egyetem; Cancer Research UK; Action Medical Research; Children's Cancer and Leukaemia Group; Deutsche Krebshilfe; University of Cincinnati; University of Pittsburgh; Chonnam National University Hwasun Hospital; Johns Hopkins University; National Cancer Institute; Emory University","keywords":"Medulloblastoma; Sonic hedgehog; Wnt signaling pathway; Medicine; Mutation; Oncology; Cohort; Cancer research; PTCH1; Germline; Internal medicine; Mutant; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000928121,0.00008735739,0.0008988932,0.0001810332,0.00001434942,0.000005234038,0.00009372018,0.000198636,0.0002147592],"category_scores_gemma":[0.001528411,0.00006045033,0.0002824107,0.0002229154,0.0001226367,0.00008631674,0.00001980481,0.0003491496,0.00004751156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001051276,"about_ca_system_score_gemma":0.0004096726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002587084,"about_ca_topic_score_gemma":0.00004671019,"domain_scores_codex":[0.9972249,0.0001835256,0.002112824,0.0001246987,0.000202627,0.0001514659],"domain_scores_gemma":[0.9955776,0.002291889,0.001257895,0.0001561864,0.0004952546,0.0002212156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002935633,0.005648835,0.7963315,0.00002007294,0.0001452728,0.0002190351,0.0000796689,0.00001735728,0.002097086,0.000833332,0.005404805,0.1889095],"study_design_scores_gemma":[0.005459559,0.00611571,0.9784684,0.00009220265,0.0001426175,0.000289927,0.00008455346,0.00003073054,0.0004809518,0.001602985,0.007187717,0.00004471645],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9817309,0.0004892573,0.00005967244,0.01531953,0.0003126649,0.0003881804,0.000001720959,0.000004557995,0.001693489],"genre_scores_gemma":[0.9963086,0.0003554788,0.002496742,0.0005434158,0.0002367339,0.00003297373,0.000003523659,0.000009449161,0.00001314266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1888648,"threshold_uncertainty_score":0.2465093,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09211854731170643,"score_gpt":0.4313613579565819,"score_spread":0.3392428106448754,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}