{"id":"W2129354516","doi":"10.1186/1750-1326-7-31","title":"LDLR-related protein 10 (LRP10) regulates amyloid precursor protein (APP) trafficking and processing: evidence for a role in Alzheimer’s disease","year":2012,"lang":"en","type":"article","venue":"Molecular Neurodegeneration","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"PerkinElmer Biosignal; Université de Sherbrooke","funders":"Alzheimer Society","keywords":"Endosome; Amyloid precursor protein; Retromer; Alpha secretase; Endocytic cycle; Amyloid precursor protein secretase; Cell biology; Golgi apparatus; LDL receptor; Ectodomain; P3 peptide; Receptor; Biology; Alzheimer's disease; Chemistry; Intracellular; Endocytosis; Endocrinology; Internal medicine; Medicine; Biochemistry; Endoplasmic reticulum; Disease; Lipoprotein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002795745,0.0002802507,0.000260685,0.0001799773,0.00015602,0.00009064687,0.00007769423,0.0001010453,0.00001976859],"category_scores_gemma":[0.0003245397,0.0002559337,0.00009707138,0.0002887286,0.00007756251,0.0004913402,0.00004261757,0.0001534606,0.00001488925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006016516,"about_ca_system_score_gemma":0.0002507371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000141231,"about_ca_topic_score_gemma":0.000005509539,"domain_scores_codex":[0.9979636,0.0001810538,0.0003464373,0.0005310886,0.0004252818,0.0005525181],"domain_scores_gemma":[0.9988741,0.00002697611,0.0001158783,0.0003030944,0.0001503682,0.0005295736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005106313,0.00263735,0.01051372,0.0006723992,0.001245167,0.0002664321,0.001081438,0.0003815837,0.9202009,0.0005702758,0.0001361483,0.05718826],"study_design_scores_gemma":[0.00538849,0.001104738,0.03373671,0.001387696,0.001412991,0.000029026,0.00004154108,0.05582004,0.8996118,0.0004803374,0.000315868,0.0006707149],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9392099,0.05472178,0.0002555777,0.0008625456,0.00002190751,0.004779025,0.00001344084,0.0001006915,0.00003506783],"genre_scores_gemma":[0.9967647,0.00003192857,0.0009701023,0.00008026963,0.00007990122,0.001731574,0.0001715367,0.00006827646,0.00010177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05755468,"threshold_uncertainty_score":0.9999893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04218694415069059,"score_gpt":0.3169525002867929,"score_spread":0.2747655561361023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}