{"id":"W2129354516","doi":"10.1186/1750-1326-7-31","title":"LDLR-related protein 10 (LRP10) regulates amyloid precursor protein (APP) trafficking and processing: evidence for a role in Alzheimer’s disease","year":2012,"lang":"en","type":"article","venue":"Molecular Neurodegeneration","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"PerkinElmer Biosignal; Université de Sherbrooke","funders":"Alzheimer Society","keywords":"Endosome; Amyloid precursor protein; Retromer; Alpha secretase; Endocytic cycle; Amyloid precursor protein secretase; Cell biology; Golgi apparatus; LDL receptor; Ectodomain; P3 peptide; Receptor; Biology; Alzheimer's disease; Chemistry; Intracellular; Endocytosis; Endocrinology; Internal medicine; Medicine; Biochemistry; Endoplasmic reticulum; Disease; Lipoprotein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001902191,0.0004742761,0.0002021537,0.0002528358,0.0001578272,0.0002951439,0.0002244121,0.000397751,0.001026779],"category_scores_gemma":[0.0001170595,0.0001065673,0.0002796276,0.0001516411,0.0003148339,0.0001538915,0.0002024415,0.0003999746,0.0005444153],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003539101,"about_ca_system_score_gemma":0.0001684482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005446635,"about_ca_topic_score_gemma":0.0003726581,"domain_scores_codex":[0.9998858,0.00001990399,0.00001182114,0.00002643086,0.00002811016,0.00002787295],"domain_scores_gemma":[0.999876,0.00001409179,0.00004504679,0.000006593361,0.00002329134,0.00003500701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005359995,0.00008391962,0.003551353,0.0002160983,0.0000235921,0.0009939159,0.00004053388,0.00005152811,0.9890253,0.0001199481,0.0003270318,0.005030819],"study_design_scores_gemma":[0.000246638,0.001534841,0.2363896,0.0001268354,0.0002773781,0.01051394,0.0003181673,0.00154393,0.7261913,0.0006014588,0.02221705,0.00003895846],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9739468,0.02069368,0.001693915,0.0005303345,0.000129706,0.00004017806,0.000370764,0.0001134961,0.002481189],"genre_scores_gemma":[0.9850047,0.01036458,0.001687267,0.0002258229,0.00009603662,0.00005412368,0.0005328501,0.00001584814,0.002018826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001026779,"threshold_uncertainty_score":0.003434896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04218694415069059,"score_gpt":0.3169525002867929,"score_spread":0.2747655561361023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}