{"id":"W2129354714","doi":"10.1073/pnas.062059799","title":"HNF-1α G319S, a transactivation-deficient mutant, is associated with altered dynamics of diabetes onset in an Oji-Cree community","year":2002,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":118,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital","funders":"National Center for Research Resources","keywords":"HNF1A; Transactivation; Diabetes mellitus; Genotype; Population; Type 2 diabetes; Age of onset; Mutation; Medicine; Endocrinology; Biology; Genetics; Disease; Internal medicine; Gene; Transcription factor; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001226242,0.0001022756,0.0002851399,0.0002609927,0.0001430366,0.00001127312,0.0003355347,0.0000829351,0.00007245249],"category_scores_gemma":[0.0008767918,0.00006707307,0.00005614049,0.00116921,0.0007505828,0.0003066763,0.00002510446,0.0002722612,4.096173e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009226221,"about_ca_system_score_gemma":0.0000363665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002434238,"about_ca_topic_score_gemma":0.00000183472,"domain_scores_codex":[0.9983108,0.00002453034,0.0003730346,0.0001521926,0.0009805646,0.0001588792],"domain_scores_gemma":[0.998805,0.0003226843,0.0004225857,0.0000185043,0.0003841586,0.00004706222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00008912729,0.001412608,0.7778364,0.000231609,0.0000938556,1.324795e-8,0.002982518,0.0001572764,0.2133055,0.002917816,0.0003359852,0.0006372972],"study_design_scores_gemma":[0.001532482,0.0006636553,0.7426367,0.0007462617,0.00007100125,0.000003405185,0.001945391,0.05910101,0.1881015,0.005051598,0.000008691388,0.000138324],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994046,0.00004156947,9.923153e-7,0.002209283,0.000008528868,0.0002101124,0.00006811201,0.00001151484,0.003403854],"genre_scores_gemma":[0.9991238,0.000008684534,0.0002978249,0.0004606858,0.000009907672,0.000008757057,0.000001947793,0.00000473151,0.0000837089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05894373,"threshold_uncertainty_score":0.2765554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05782332431468007,"score_gpt":0.2885834404118529,"score_spread":0.2307601160971728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}