{"id":"W2129379931","doi":"10.1093/jat/33.4.198","title":"Therapeutic Drug Monitoring of Clozapine and Norclozapine in Human Serum Using Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry","year":2009,"lang":"en","type":"article","venue":"Journal of Analytical Toxicology","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Surrey Memorial Hospital","funders":"","keywords":"Chemistry; Chromatography; Selected reaction monitoring; Electrospray ionization; Metabolite; Detection limit; Protein precipitation; Triple quadrupole mass spectrometer; Tandem mass spectrometry; Mass spectrometry; Therapeutic drug monitoring; Pharmacokinetics; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000504777,0.0001797878,0.0005836557,0.0003982885,0.00005939805,0.0000114622,0.0001799463,0.0001430917,0.00001609599],"category_scores_gemma":[0.00006205247,0.0001534382,0.0001530361,0.0003822328,0.0001499509,0.00001237477,0.00003255732,0.0002572006,1.626922e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003321345,"about_ca_system_score_gemma":0.00004659632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002042381,"about_ca_topic_score_gemma":0.000002783273,"domain_scores_codex":[0.9985811,0.00007456031,0.0006534953,0.0002050549,0.0001688433,0.0003169354],"domain_scores_gemma":[0.9992572,0.00002829693,0.000338264,0.0001578284,0.0001153078,0.0001030968],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002085094,0.0001428989,0.08386924,0.00002019836,0.0001822686,0.00001417163,0.00002711285,0.00007796242,0.9147972,0.0002990696,0.00001424277,0.0003470923],"study_design_scores_gemma":[0.00205763,0.00525842,0.3229339,0.0000725158,0.0001629695,0.0001985597,0.0001836004,0.0002346956,0.6677213,0.0005530287,0.0003559409,0.0002673883],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939118,0.004908965,0.0004559105,0.0002652823,0.0001349595,0.00006922761,0.000002073636,0.000002550023,0.0002492532],"genre_scores_gemma":[0.9927151,0.004753227,0.002065903,0.00009350723,0.000329643,4.651607e-7,9.016092e-7,0.00001090106,0.00003039951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2470759,"threshold_uncertainty_score":0.6257029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01729137596383222,"score_gpt":0.2928201511979391,"score_spread":0.2755287752341069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}