{"id":"W2129380367","doi":"10.1093/hmg/ddu431","title":"Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk","year":2014,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; McGill University Health Centre; Université de Montréal; Université Laval; Centre hospitalier universitaire de Québec; McGill University; McGill University and Génome Québec Innovation Centre; Institute of Aging","funders":"Common Fund; Medical Research and Materiel Command; National Institute of Neurological Disorders and Stroke; National Cancer Institute; National Institute on Drug Abuse; Biomedical Research Council; Instituto de Salud Carlos III; Medical Research Council; National Institute of Mental Health; Ministero dello Sviluppo Economico; National Health and Medical Research Council; Oulun Yliopisto; Deutsche Krebshilfe; Medizinischen Hochschule Hannover; Norges Forskningsråd; Singapore Eye Research Institute; Stockholms Läns Landsting; Kuopion Yliopistollinen Sairaala; NIH Office of the Director; National Medical Research Council; Ministério da Ciência, Tecnologia e Inovação; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Robert Bosch Stiftung; Kementerian Sains, Teknologi dan Inovasi; Karolinska Institutet; ZonMw; National Breast Cancer Foundation; KWF Kankerbestrijding; Cancer Council Tasmania; Francis Crick Institute; World Health Organization; Fondation du cancer du sein du Québec; Wellcome Trust; Cancer Research UK; Academy of Finland; Génome Québec; National Institute for Health and Care Research; Associazione Italiana per la Ricerca sul Cancro; National Heart, Lung, and Blood Institute; Itä-Suomen Yliopisto; Lon V. Smith Foundation; Ministère du Développement Économique, de l’Innovation et de l’Exportation; National Institutes of Health; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Deutsche Gesetzliche Unfallversicherung; David F. and Margaret T. Grohne Family Foundation; Deutsches Krebsforschungszentrum; Breast Cancer Research Foundation; McGill University; Canadian Institutes of Health Research; Fonds Wetenschappelijk Onderzoek; Cancerfonden; Harvard University; Deutschen Konsortium für Translationale Krebsforschung; Université de Genève; National Human Genome Research Institute; Cancer Council Victoria; California Department of Public Health; U.S. Army; Mayo Clinic; Broad Institute; Helsingin ja Uudenmaan Sairaanhoitopiiri","keywords":"Biology; Breast cancer; Identification (biology); Genetics; Chromosome; Cancer; Computational biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007239521,0.0005445565,0.0006913675,0.001139106,0.0003002165,0.0005809723,0.0006747346,0.0006879747,0.002162562],"category_scores_gemma":[0.003262045,0.0002647785,0.0008077087,0.001393971,0.0002660232,0.0001553643,0.0003080766,0.0005266394,0.00034493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002034301,"about_ca_system_score_gemma":0.0002269122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003013001,"about_ca_topic_score_gemma":0.003123788,"domain_scores_codex":[0.9992422,0.000168096,0.00006827183,0.0003173535,0.0001224194,0.00008161877],"domain_scores_gemma":[0.9983189,0.0006620794,0.0005358963,0.0001928903,0.0001512674,0.0001389702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002816761,0.0001377311,0.9129725,0.0001340147,0.001003772,0.003629803,0.0003971865,0.0004975832,0.06298205,0.0001831451,0.0005980796,0.01464737],"study_design_scores_gemma":[0.0001581375,0.0002183111,0.9914827,0.00001455846,0.0003313636,0.002773176,0.00007225754,0.001014097,0.003039813,0.0001286693,0.0007523746,0.00001460107],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977753,0.0004793126,0.0009454789,0.00008784801,0.00001008071,0.0000180866,0.0004274143,0.00003157116,0.0002249372],"genre_scores_gemma":[0.997322,0.0001391761,0.001421686,0.00005432676,0.0000284471,0.00002651319,0.0006953633,0.00001400396,0.0002984819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003013001,"threshold_uncertainty_score":0.007234514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01241207121381352,"score_gpt":0.2572001735357465,"score_spread":0.244788102321933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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