{"id":"W2129380367","doi":"10.1093/hmg/ddu431","title":"Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk","year":2014,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; McGill University Health Centre; Université de Montréal; Université Laval; Centre hospitalier universitaire de Québec; McGill University; McGill University and Génome Québec Innovation Centre; Institute of Aging","funders":"Common Fund; Medical Research and Materiel Command; National Institute of Neurological Disorders and Stroke; National Cancer Institute; National Institute on Drug Abuse; Biomedical Research Council; Instituto de Salud Carlos III; Medical Research Council; National Institute of Mental Health; Ministero dello Sviluppo Economico; National Health and Medical Research Council; Oulun Yliopisto; Deutsche Krebshilfe; Medizinischen Hochschule Hannover; Norges Forskningsråd; Singapore Eye Research Institute; Stockholms Läns Landsting; Kuopion Yliopistollinen Sairaala; NIH Office of the Director; National Medical Research Council; Ministério da Ciência, Tecnologia e Inovação; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Robert Bosch Stiftung; Kementerian Sains, Teknologi dan Inovasi; Karolinska Institutet; ZonMw; National Breast Cancer Foundation; KWF Kankerbestrijding; Cancer Council Tasmania; Francis Crick Institute; World Health Organization; Fondation du cancer du sein du Québec; Wellcome Trust; Cancer Research UK; Academy of Finland; Génome Québec; National Institute for Health and Care Research; Associazione Italiana per la Ricerca sul Cancro; National Heart, Lung, and Blood Institute; Itä-Suomen Yliopisto; Lon V. Smith Foundation; Ministère du Développement Économique, de l’Innovation et de l’Exportation; National Institutes of Health; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Deutsche Gesetzliche Unfallversicherung; David F. and Margaret T. Grohne Family Foundation; Deutsches Krebsforschungszentrum; Breast Cancer Research Foundation; McGill University; Canadian Institutes of Health Research; Fonds Wetenschappelijk Onderzoek; Cancerfonden; Harvard University; Deutschen Konsortium für Translationale Krebsforschung; Université de Genève; National Human Genome Research Institute; Cancer Council Victoria; California Department of Public Health; U.S. Army; Mayo Clinic; Broad Institute; Helsingin ja Uudenmaan Sairaanhoitopiiri","keywords":"Biology; Breast cancer; Identification (biology); Genetics; Chromosome; Cancer; Computational biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002628541,0.0001169055,0.0001071154,0.00005996099,0.0000924895,0.0000306635,0.0001155845,0.0001009676,0.000001516075],"category_scores_gemma":[0.0000254013,0.00009561426,0.00002994,0.000120514,0.00006175686,0.000003510689,0.00002424752,0.00007610396,4.192869e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001331761,"about_ca_system_score_gemma":0.0000210213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003900981,"about_ca_topic_score_gemma":0.0001172988,"domain_scores_codex":[0.9990883,0.000139595,0.0002274156,0.0002469648,0.0001761619,0.0001215049],"domain_scores_gemma":[0.9992553,0.00001251706,0.0002615008,0.0003245835,0.000118489,0.0000276133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00001223,0.00008879585,0.02355104,0.000009529376,0.00001806139,4.144798e-7,0.0001330496,0.0007513894,0.9737611,0.0003763186,0.000003645462,0.001294397],"study_design_scores_gemma":[0.0005016745,0.0001996133,0.7749329,0.00001901577,0.00004027599,0.000003191164,0.00001697599,0.0005882532,0.2232091,0.0001167115,0.0002470027,0.0001253858],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846257,0.0001759716,0.01464357,0.0001374612,0.00002780017,0.0002327424,0.00006109782,0.000003546485,0.0000920943],"genre_scores_gemma":[0.9990051,0.0004311262,0.00009652298,0.00009057007,0.00007874643,0.00003080952,0.0002225908,0.000020417,0.00002405483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7513818,"threshold_uncertainty_score":0.3899036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01241207121381352,"score_gpt":0.2572001735357465,"score_spread":0.244788102321933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}