{"id":"W2129391217","doi":"10.1210/en.2002-0026","title":"Inhibition of F-Box Protein p45SKP2 Expression and Stabilization of Cyclin-Dependent Kinase Inhibitor p27KIP1 in Vitamin D Analog-Treated Cancer Cells","year":2003,"lang":"en","type":"article","venue":"Endocrinology","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University","funders":"","keywords":"Biology; Cyclin-dependent kinase; Kinase; Protein kinase A; Gene expression; Internal medicine; Endocrinology; Protein subunit; Ubiquitin ligase; Cancer cell; Protein turnover; Molecular biology; Cancer research; Cell cycle; Protein biosynthesis; Ubiquitin; Gene; Cancer; Cell biology; Biochemistry; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001082175,0.0001722358,0.0004213902,0.0003572429,0.00002213561,0.000002722592,0.00003610611,0.000170572,0.000131591],"category_scores_gemma":[0.0001502875,0.0001666859,0.00005092847,0.000305202,0.000149293,0.00005668377,0.00004365894,0.0002348064,0.00000272812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001526008,"about_ca_system_score_gemma":0.0001301154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004522277,"about_ca_topic_score_gemma":0.0002993949,"domain_scores_codex":[0.9984266,0.0002036357,0.0005240696,0.0003561168,0.0001990234,0.0002905264],"domain_scores_gemma":[0.9992581,0.00003789635,0.0002315068,0.000264369,0.0001330724,0.00007504317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002550297,0.00029199,0.01158511,0.0002075025,0.00002137703,0.0001093314,0.0002864942,0.0001253942,0.9856695,0.0002500178,0.00003552868,0.001162762],"study_design_scores_gemma":[0.00398964,0.0004449268,0.004231818,0.0004575184,0.00004781377,0.00003079895,0.0001784616,0.00003607251,0.9901965,0.0001000443,0.0001658682,0.0001205784],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968704,0.001140894,0.0003367903,0.00007149109,0.0001256457,0.0009179233,0.00004419382,0.00002784206,0.0004648019],"genre_scores_gemma":[0.9988675,0.0003222012,0.0005008678,0.00002736616,0.00002318718,0.0001136118,0.00003427736,0.00002624748,0.00008477446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00735329,"threshold_uncertainty_score":0.6797255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01106588991468458,"score_gpt":0.2550410275109947,"score_spread":0.2439751375963101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}