{"id":"W2129399870","doi":"10.1093/carcin/21.4.827","title":"Inhibition of N-methyl-N-nitrosourea- and 7,12-dimethylbenz[a] anthracene-induced rat mammary tumorigenesis by dietary cholesterol is independent of Ha-ras mutations","year":2000,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"DMBA; Endocrinology; Internal medicine; Carcinogen; Cholesterol; Carcinogenesis; HMG-CoA reductase; 7,12-Dimethylbenz[a]anthracene; Reductase; Mammary tumor; Biology; Mevalonate pathway; Enzyme; Tumor initiation; Mammary gland; Chemistry; Biochemistry; Cancer; Medicine; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002015438,0.0002904781,0.0004491375,0.000121158,0.0001035383,0.00001880162,0.0001747862,0.0002225185,0.00008613167],"category_scores_gemma":[0.00002832685,0.000301701,0.0002053762,0.000180735,0.0001566884,0.000021838,0.00008501705,0.00008844745,0.000003274842],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001933335,"about_ca_system_score_gemma":0.0001224454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004210134,"about_ca_topic_score_gemma":0.00009431723,"domain_scores_codex":[0.9982432,0.0001389892,0.0005017239,0.0005411719,0.0002755159,0.0002994724],"domain_scores_gemma":[0.9989084,0.0000255543,0.0002026531,0.0005372738,0.0001642431,0.0001618763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001357864,0.0001223219,0.007969961,0.00008911146,0.0001052908,5.077961e-7,0.0002588484,0.00001823023,0.9704953,0.000004239388,0.002331093,0.01846929],"study_design_scores_gemma":[0.001076899,0.0002388956,0.04292264,0.00002792686,0.0001688061,0.00002171064,0.0001566924,0.00001363516,0.9469317,0.00003513673,0.00812361,0.0002824097],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989378,0.008771776,0.0001180234,0.0001237367,0.0007407859,0.000299938,0.0003164512,0.00001408663,0.0002372271],"genre_scores_gemma":[0.9936603,0.004058997,0.0002854434,0.0002703466,0.000887491,0.00005016262,0.0002651323,0.00004369133,0.0004784254],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03495268,"threshold_uncertainty_score":0.9999435,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01220724416856138,"score_gpt":0.2430307311785707,"score_spread":0.2308234870100093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}