{"id":"W2129417347","doi":"10.5772/23015","title":"Regulation of a-Synuclein Membrane Binding and Its Implications","year":2012,"lang":"en","type":"book-chapter","venue":"InTech eBooks","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Parkinson Society Canada","keywords":"Pars compacta; Substantia nigra; Neuroscience; Neurodegeneration; Dementia with Lewy bodies; Parkinson's disease; Dopaminergic; Locus coeruleus; Lewy body; Parkinsonism; Psychology; Biology; Dementia; Dopamine; Medicine; Pathology; Disease; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007714581,0.0002172859,0.000358533,0.0002130367,0.00005036738,0.000007459561,0.00005445718,0.0002683194,0.0002598177],"category_scores_gemma":[0.00001811551,0.0001963724,0.0001096108,0.00001069475,0.00004725278,0.00002878904,0.00005403102,0.0001568518,0.00007185728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006964529,"about_ca_system_score_gemma":0.00005651792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005008604,"about_ca_topic_score_gemma":0.000002560719,"domain_scores_codex":[0.9991417,0.000005998119,0.0002671565,0.0002518856,0.000185192,0.0001480807],"domain_scores_gemma":[0.9991668,0.00003604408,0.0002100712,0.000304962,0.0001274786,0.0001546033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001114297,0.00006842137,0.00008570239,0.0003465264,0.0005495175,0.0000150547,0.0001192678,1.840185e-8,0.842734,0.1071623,0.0001482953,0.04865943],"study_design_scores_gemma":[0.00148154,0.0002733322,0.002078559,0.001426778,0.001666552,0.000109979,0.00001186261,0.000009900748,0.7345621,0.01815573,0.2398113,0.0004123348],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"other","genre_gemma":"empirical","genre_scores_codex":[0.05162668,0.002888774,0.0003008717,0.000194775,0.0008477632,0.001764435,0.0004551186,0.0002160893,0.9417055],"genre_scores_gemma":[0.864355,0.0000858131,0.000258091,0.00002593315,0.0002651559,0.00003122477,0.00008166432,0.00005358955,0.1348435],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.8127284,"threshold_uncertainty_score":0.8007834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03996355456957461,"score_gpt":0.2757170040121428,"score_spread":0.2357534494425682,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}