{"id":"W2129447411","doi":"10.1186/s13073-015-0233-4","title":"HOTAIR and its surrogate DNA methylation signature indicate carboplatin resistance in ovarian cancer","year":2015,"lang":"en","type":"article","venue":"Genome Medicine","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":153,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of British Columbia","funders":"National Cancer Institute; BC Cancer Agency; Seventh Framework Programme; Medical Research Council; Cancer Center, University of Kansas; Inger and John Fredriksen Foundation for Ovarian Cancer Research; Haukeland Universitetssjukehus; Universitair Medisch Centrum Groningen; RWTH Aachen University; Rijksuniversiteit Groningen; Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences; Max-Planck-Gesellschaft; University College London; University of Southern California; Chinese Academy of Sciences; University of New South Wales; Kreftforeningen; Directorate for Biological Sciences; National Institutes of Health; University College London Hospitals NHS Foundation Trust; European Commission; Helse Vest; KU Leuven; Universitetet i Bergen; National Institute for Health and Care Research; Norges Forskningsråd","keywords":"HOTAIR; Carboplatin; Ovarian cancer; DNA methylation; Oncology; Cancer research; Cancer stem cell; Cisplatin; Long non-coding RNA; Biology; Medicine; Internal medicine; Cancer; Chemotherapy; Genetics; Downregulation and upregulation; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003823181,0.0001454687,0.0003497612,0.0006631712,0.000169032,0.0003675629,0.0002223604,0.0003397707,0.001180101],"category_scores_gemma":[0.001311451,0.0001513981,0.0002272209,0.0005835045,0.0003016723,0.0001468841,0.0003745156,0.0002894734,0.0001135541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002709732,"about_ca_system_score_gemma":0.0001090709,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009476176,"about_ca_topic_score_gemma":0.001078629,"domain_scores_codex":[0.9997681,0.00005004809,0.00002609083,0.000079609,0.0000415306,0.00003468476],"domain_scores_gemma":[0.9991624,0.0002491654,0.0003746428,0.00008038791,0.00006752892,0.00006585153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001425851,0.00002797937,0.9634889,0.00004789474,0.0001246482,0.0001040958,0.00008972295,0.0003683169,0.0293793,0.00003096112,0.00007664793,0.004835805],"study_design_scores_gemma":[0.00001485042,0.0001783364,0.9932299,0.000004127362,0.00007963111,0.0005919008,0.00006532708,0.0006997149,0.004848807,0.00005109097,0.0002329168,0.000003404533],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993626,0.0002457734,0.0001483513,0.00001366212,0.000001376138,0.000006081899,0.00009463235,0.000004647429,0.0001227572],"genre_scores_gemma":[0.9996412,0.00004363923,0.00009776015,0.000007449264,0.000001805196,0.000003980727,0.0001406304,0.000001466325,0.00006219403],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001180101,"threshold_uncertainty_score":0.003947854,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02141474143185696,"score_gpt":0.2939348556056186,"score_spread":0.2725201141737616,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}