{"id":"W2129447411","doi":"10.1186/s13073-015-0233-4","title":"HOTAIR and its surrogate DNA methylation signature indicate carboplatin resistance in ovarian cancer","year":2015,"lang":"en","type":"article","venue":"Genome Medicine","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":153,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of British Columbia","funders":"National Cancer Institute; BC Cancer Agency; Seventh Framework Programme; Medical Research Council; Cancer Center, University of Kansas; Inger and John Fredriksen Foundation for Ovarian Cancer Research; Haukeland Universitetssjukehus; Universitair Medisch Centrum Groningen; RWTH Aachen University; Rijksuniversiteit Groningen; Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences; Max-Planck-Gesellschaft; University College London; University of Southern California; Chinese Academy of Sciences; University of New South Wales; Kreftforeningen; Directorate for Biological Sciences; National Institutes of Health; University College London Hospitals NHS Foundation Trust; European Commission; Helse Vest; KU Leuven; Universitetet i Bergen; National Institute for Health and Care Research; Norges Forskningsråd","keywords":"HOTAIR; Carboplatin; Ovarian cancer; DNA methylation; Oncology; Cancer research; Cancer stem cell; Cisplatin; Long non-coding RNA; Biology; Medicine; Internal medicine; Cancer; Chemotherapy; Genetics; Downregulation and upregulation; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006856215,0.0001704329,0.0002199334,0.0001639387,0.00004122064,0.000009067478,0.0002115213,0.0002358425,0.00005556884],"category_scores_gemma":[0.000335958,0.0001552909,0.00002240175,0.0003462669,0.00007597129,0.000005332034,0.0001468839,0.0002655222,0.000004714522],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009404748,"about_ca_system_score_gemma":0.0002131328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001512044,"about_ca_topic_score_gemma":0.001345155,"domain_scores_codex":[0.9985421,0.0001302259,0.0002387847,0.0004369673,0.0003280321,0.0003238572],"domain_scores_gemma":[0.9991982,0.00001229835,0.00009242641,0.0003319483,0.0001476721,0.0002174324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002115411,0.00001202007,0.0000630129,0.00003402286,0.00003893622,0.00002876984,0.0004805963,0.0001692122,0.9976044,0.0001294299,0.0006730087,0.0005550095],"study_design_scores_gemma":[0.01096253,0.0009852577,0.01503839,0.0002978401,0.0001055386,0.00002934672,0.0005529426,0.0004934683,0.8578341,0.002459365,0.110363,0.0008781665],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8820114,0.1042272,0.002096464,0.006580883,0.0004116205,0.0009407187,0.00005684953,0.00002690869,0.003647979],"genre_scores_gemma":[0.9965907,0.001113773,0.0002035056,0.0003006472,0.0003178212,0.00005935141,0.000148992,0.00003193208,0.001233282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1397703,"threshold_uncertainty_score":0.6332579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02141474143185696,"score_gpt":0.2939348556056186,"score_spread":0.2725201141737616,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}