{"id":"W2129447528","doi":"10.1074/jbc.m803090200","title":"The Molecular Cloning of Artemisinic Aldehyde Δ11(13) Reductase and Its Role in Glandular Trichome-dependent Biosynthesis of Artemisinin in Artemisia annua","year":2008,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":305,"is_retracted":false,"has_abstract":true,"ca_institutions":"Plant Biotechnology Institute","funders":"Vlaamse Interuniversitaire Raad; Universiteit Gent","keywords":"Artemisia annua; Artemisinin; Biosynthesis; Double bond; Trichome; Reductase; Stereochemistry; Biology; Biochemistry; Chemistry; Aldehyde; Enzyme; Botany; Organic chemistry; Plasmodium falciparum","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009997762,0.0002755694,0.0005967946,0.00006024077,0.00005963435,0.00001051932,0.0004707611,0.0004873821,0.00001529502],"category_scores_gemma":[0.001214767,0.0001896241,0.0002139129,0.0002303879,0.0003407758,0.00001059751,0.000127637,0.0003613139,4.61954e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003079381,"about_ca_system_score_gemma":0.0001416888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007808517,"about_ca_topic_score_gemma":0.000002236891,"domain_scores_codex":[0.9977206,0.0001512685,0.001127212,0.0003560276,0.0002894689,0.0003554169],"domain_scores_gemma":[0.9984292,0.0002159204,0.000758432,0.0002974342,0.0001480862,0.0001508908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006722286,0.000236609,0.01178696,0.00006371016,0.0000749603,0.0001520965,0.00004106307,0.00003882623,0.9863705,0.000003177986,0.00005192112,0.0005079496],"study_design_scores_gemma":[0.0009160144,0.0002176602,0.005206408,0.0001712146,0.00002384823,0.0008228363,0.0003305431,0.00003203816,0.9916315,0.00005933551,0.0003767417,0.0002118536],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868179,0.01251832,0.000008036174,0.000159615,0.00002985439,0.00009427257,0.00006005808,0.000003289076,0.0003086808],"genre_scores_gemma":[0.9941779,0.00549755,0.0001088316,0.00002504426,0.0001010383,0.000004335367,0.00001871926,0.00001246615,0.0000541191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007360019,"threshold_uncertainty_score":0.7732645,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01291587410076631,"score_gpt":0.2233069068726305,"score_spread":0.2103910327718642,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}