{"id":"W2129454070","doi":"10.4049/jimmunol.1000872","title":"Distinct Roles of Hepatocyte- and Myeloid Cell-Derived IL-1 Receptor Antagonist during Endotoxemia and Sterile Inflammation in Mice","year":2010,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Université de Genève; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Novartis Foundation; Fondation Rheumasearch; Arthritis Foundation; National Science Foundation","keywords":"Inflammation; Proinflammatory cytokine; Myeloid; Hepatocyte; Interleukin 1 receptor antagonist; Biology; Receptor antagonist; Immunology; Systemic inflammation; Receptor; In vitro; Antagonist","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000496452,0.001000725,0.0007348491,0.001086119,0.0002882833,0.0007419356,0.0005122559,0.0007852098,0.001027172],"category_scores_gemma":[0.0003047908,0.0006231882,0.000538258,0.0002473406,0.001022355,0.0007170417,0.0005270921,0.002153552,0.0006241635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004615031,"about_ca_system_score_gemma":0.0004677026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002412804,"about_ca_topic_score_gemma":0.0003741252,"domain_scores_codex":[0.9992301,0.0001580192,0.00007633065,0.0001882876,0.0001501251,0.0001971365],"domain_scores_gemma":[0.9991723,0.0000660114,0.0003190233,0.00008136377,0.00004476047,0.0003166061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008510945,0.00009662438,0.0002184717,0.00003482493,0.000006637714,0.0001137704,0.00003254497,0.00004976145,0.9972895,0.0003018203,0.00003715547,0.0009677364],"study_design_scores_gemma":[0.0004026503,0.002245905,0.01420353,0.00004161755,0.0001087598,0.00140664,0.0001402353,0.001638528,0.9759699,0.0005171301,0.003289652,0.00003533336],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878848,0.003229392,0.005910562,0.0003583628,0.00006422737,0.00007664551,0.0006663152,0.0002874838,0.001522394],"genre_scores_gemma":[0.9874827,0.001520531,0.005556174,0.0002774803,0.000044921,0.0002282861,0.0009187743,0.0001556472,0.003815602],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001086119,"threshold_uncertainty_score":0.003436208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004322297217230237,"score_gpt":0.200180261886374,"score_spread":0.1958579646691438,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}