{"id":"W2129505260","doi":"10.2337/db09-1452","title":"β-Cell Failure in Diet-Induced Obese Mice Stratified According to Body Weight Gain: Secretory Dysfunction and Altered Islet Lipid Metabolism Without Steatosis or Reduced β-Cell Mass","year":2010,"lang":"en","type":"article","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":146,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Canadian Institutes of Health Research; National Institutes of Health; Canadian Diabetes Association; School of Medicine, Boston University","keywords":"Internal medicine; Endocrinology; Islet; Carbohydrate metabolism; Lipid metabolism; Lipolysis; Steatosis; Insulin; Triglyceride; Metabolism; Glucose homeostasis; Chemistry; Insulin resistance; Biology; Medicine; Cholesterol; Adipose tissue","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00044819,0.001174098,0.0008821784,0.001720572,0.0002947379,0.0005915141,0.000356424,0.000440407,0.002313918],"category_scores_gemma":[0.0001957596,0.0004791122,0.0006182068,0.0005814831,0.0004876932,0.0004971007,0.0005067417,0.001501942,0.0007283516],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002812184,"about_ca_system_score_gemma":0.0001993971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002931011,"about_ca_topic_score_gemma":0.0003975212,"domain_scores_codex":[0.9995965,0.00004155112,0.0000596323,0.0001437515,0.00007688212,0.00008169461],"domain_scores_gemma":[0.9992673,0.00003491843,0.0002928364,0.00007550867,0.00003744247,0.0002920962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003162263,0.0004629261,0.002620303,0.00005090737,0.00003781997,0.00008837045,0.0000321896,0.00003499203,0.9917337,0.00004083955,0.0000515742,0.001684251],"study_design_scores_gemma":[0.001624063,0.01315232,0.4019355,0.0001128024,0.000593205,0.003561662,0.0004209492,0.001993465,0.5725709,0.0003787535,0.003538237,0.0001180966],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971793,0.0006812981,0.0008758312,0.00005566103,0.00002167595,0.00005501287,0.0006304812,0.00007321495,0.0004275551],"genre_scores_gemma":[0.9881169,0.001211663,0.003645298,0.00031393,0.00005479191,0.0003227728,0.00289805,0.0001797917,0.003256818],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002313918,"threshold_uncertainty_score":0.007740796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0128845275611644,"score_gpt":0.240728142592878,"score_spread":0.2278436150317136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}