{"id":"W2129515100","doi":"10.1124/mol.106.024273","title":"A Single Decoy Oligodeoxynucleotides Targeting Multiple Oncoproteins Produces Strong Anticancer Effects","year":2006,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Heart Institute","funders":"","keywords":"Decoy; Targeted therapy; Transcription factor; In vivo; Cancer research; Biology; E2F; Cancer; Pharmacology; Computational biology; Gene; Genetics; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000415072,0.0006762836,0.0008076325,0.0005099098,0.0002238866,0.0003564566,0.0002938538,0.0004439616,0.001135639],"category_scores_gemma":[0.0002903421,0.0003385796,0.0002930726,0.0002879032,0.0004324513,0.0002669967,0.0003159955,0.0009711388,0.0003969249],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004325348,"about_ca_system_score_gemma":0.0004352512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004945245,"about_ca_topic_score_gemma":0.001119669,"domain_scores_codex":[0.9996,0.00004797573,0.0000328237,0.0001089485,0.0001293308,0.00008108125],"domain_scores_gemma":[0.9996233,0.0001191952,0.00006336587,0.00007045761,0.00004135816,0.00008232043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004256868,0.00001530636,0.00004775229,0.00001595596,0.00000413084,0.00001476698,0.000003556704,0.00004566199,0.9986413,0.00009968874,0.00002315141,0.001046139],"study_design_scores_gemma":[0.000007981384,0.0001480075,0.00029066,0.000001101968,0.00001117125,0.00008720115,0.000002165601,0.0002433069,0.9986724,0.00002090508,0.0005130515,0.00000207301],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9669777,0.005147379,0.01977002,0.0002513949,0.0001579605,0.0001390066,0.0002699261,0.0005588268,0.00672775],"genre_scores_gemma":[0.9887426,0.001220385,0.005936671,0.00009653869,0.00003638789,0.00006710985,0.0002775203,0.00007025423,0.003552487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001135639,"threshold_uncertainty_score":0.00379914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006565180214880819,"score_gpt":0.2517830501047578,"score_spread":0.245217869889877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}