{"id":"W2129516622","doi":"10.6000/1929-2279.2014.03.01.6","title":"B5H7, a Morpholine Derivative of 23-Hydroxybetulinic Acid, Reverses Doxorubicin Resistance in HepG2/ADM","year":2014,"lang":"en","type":"article","venue":"Journal of cancer research updates","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Doxorubicin; P-glycoprotein; Efflux; Multiple drug resistance; Cytotoxicity; Chemistry; Pharmacology; Chemotherapy; Cancer cell; Cisplatin; Intracellular; Drug resistance; Cancer; Cancer research; Biochemistry; In vitro; Medicine; Biology; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001217126,0.0001795872,0.0001740934,0.0002222016,0.0001238025,0.0001200251,0.0001646541,0.0001893834,0.001235676],"category_scores_gemma":[0.00006909837,0.00007456398,0.0001926271,0.0001088865,0.0001437301,0.0001583924,0.00009816603,0.0002895026,0.0002667476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001403626,"about_ca_system_score_gemma":0.0001662764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008254723,"about_ca_topic_score_gemma":0.001425029,"domain_scores_codex":[0.9999444,0.00001578043,0.000004995122,0.000007801202,0.0000142744,0.00001259668],"domain_scores_gemma":[0.9999623,0.0000068103,0.000008108337,0.000003814113,0.000006373582,0.00001258432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002161727,0.00007397289,0.0002981357,0.0001040453,0.00001514139,0.0001271285,0.00001685294,0.0001399501,0.9876414,0.0001714172,0.0002352876,0.01096045],"study_design_scores_gemma":[0.00004896381,0.001784624,0.003113961,0.00001254666,0.00003786276,0.0004828252,0.00002806384,0.0006317459,0.9777996,0.00004098577,0.01600904,0.000009866378],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9746501,0.01723586,0.002701875,0.000267348,0.0001301204,0.00008521649,0.0002998602,0.0001194692,0.00451013],"genre_scores_gemma":[0.986067,0.006251627,0.003299971,0.0001880348,0.00002884462,0.0000267437,0.0006707122,0.00001937391,0.003447832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001235676,"threshold_uncertainty_score":0.004133701,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04106386093168302,"score_gpt":0.3935673316733256,"score_spread":0.3525034707416426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}