{"id":"W2129522972","doi":"10.1158/1078-0432.ccr-07-0318","title":"Tolerability, Pharmacodynamics, and Pharmacokinetics Studies of Depsipeptide (Romidepsin) in Patients with Acute Myelogenous Leukemia or Advanced Myelodysplastic Syndromes","year":2008,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":132,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute; Leukemia and Lymphoma Society","keywords":"Medicine; Neutropenia; Tolerability; Depsipeptide; Pharmacology; Pharmacodynamics; Internal medicine; Leukemia; Myeloid leukemia; Oncology; Pharmacokinetics; Chemotherapy; Adverse effect; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004846058,0.000450892,0.0006123867,0.000101708,0.0001208153,0.0002104012,0.0001585754,0.0002221796,0.0005795957],"category_scores_gemma":[0.0007474466,0.000122559,0.0003220077,0.0001418991,0.0002260226,0.0001632174,0.00008690327,0.0005493315,0.0001718019],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002457199,"about_ca_system_score_gemma":0.0001614842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002284871,"about_ca_topic_score_gemma":0.0003925021,"domain_scores_codex":[0.9997573,0.0001411913,0.00001596693,0.00003192001,0.00003418595,0.00001937382],"domain_scores_gemma":[0.9996294,0.0001103241,0.0001376068,0.00001818471,0.0000248072,0.00007968432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1522885,0.006661015,0.1672581,0.0009374112,0.001447209,0.002684946,0.0006737004,0.007596958,0.3943139,0.0002650758,0.002399235,0.2634739],"study_design_scores_gemma":[0.0149147,0.5274006,0.3834591,0.00006667869,0.001021552,0.007228777,0.0001959955,0.005752346,0.05224694,0.0002083017,0.007463822,0.00004122567],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972222,0.001715695,0.0004341599,0.00007622995,0.000007660896,0.00004832973,0.00009786794,0.00002089304,0.0003771401],"genre_scores_gemma":[0.9985153,0.0005536688,0.0003756218,0.000110993,0.00002661426,0.000038301,0.0002004027,0.000004992756,0.0001739853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006123867,"threshold_uncertainty_score":0.002562821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1281728241686761,"score_gpt":0.4773455310330927,"score_spread":0.3491727068644166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}