{"id":"W2129578178","doi":"10.1210/en.2009-1122","title":"Palmitate Attenuates Insulin Signaling and Induces Endoplasmic Reticulum Stress and Apoptosis in Hypothalamic Neurons: Rescue of Resistance and Apoptosis through Adenosine 5′ Monophosphate-Activated Protein Kinase Activation","year":2009,"lang":"en","type":"article","venue":"Endocrinology","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":237,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto General Hospital; University Health Network","funders":"Canadian Institutes of Health Research","keywords":"Lipotoxicity; Insulin resistance; Internal medicine; Endocrinology; Biology; Endoplasmic reticulum; Insulin receptor; Unfolded protein response; Protein kinase B; Kinase; Insulin; Signal transduction; Protein kinase A; Glucose homeostasis; Cell biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001656897,0.0006738741,0.0006496896,0.0003323453,0.0002242113,0.0002601616,0.0003940011,0.0003855469,0.001132727],"category_scores_gemma":[0.00013454,0.0002414763,0.0005691631,0.0002603678,0.0002778688,0.0003584358,0.000344679,0.0009859101,0.0003540615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002685655,"about_ca_system_score_gemma":0.0005015107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001036108,"about_ca_topic_score_gemma":0.001671216,"domain_scores_codex":[0.9998547,0.00001740671,0.00002664854,0.00002757365,0.00002633938,0.00004724852],"domain_scores_gemma":[0.99989,0.00001101072,0.00002842989,0.0000197054,0.0000165711,0.00003426935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008862425,0.00009486167,0.0000987563,0.0001014829,0.00001798592,0.00008816146,0.00002378178,0.00005819503,0.9968458,0.00004567741,0.00003281403,0.001706312],"study_design_scores_gemma":[0.00009764225,0.001116999,0.003071166,0.00001486698,0.0000391069,0.0002377404,0.00006402327,0.0004309602,0.9936473,0.00009091751,0.001181854,0.000007410503],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938584,0.002723,0.001598935,0.0001421983,0.00007610922,0.00004759638,0.0003512375,0.00009241259,0.001110255],"genre_scores_gemma":[0.9881252,0.004208552,0.003193345,0.0001064528,0.00003170846,0.0001234274,0.000797745,0.00004389615,0.003369779],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001132727,"threshold_uncertainty_score":0.003789365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01089637581867875,"score_gpt":0.234535451560806,"score_spread":0.2236390757421273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}