{"id":"W2129578178","doi":"10.1210/en.2009-1122","title":"Palmitate Attenuates Insulin Signaling and Induces Endoplasmic Reticulum Stress and Apoptosis in Hypothalamic Neurons: Rescue of Resistance and Apoptosis through Adenosine 5′ Monophosphate-Activated Protein Kinase Activation","year":2009,"lang":"en","type":"article","venue":"Endocrinology","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":237,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto General Hospital; University Health Network","funders":"Canadian Institutes of Health Research","keywords":"Lipotoxicity; Insulin resistance; Internal medicine; Endocrinology; Biology; Endoplasmic reticulum; Insulin receptor; Unfolded protein response; Protein kinase B; Kinase; Insulin; Signal transduction; Protein kinase A; Glucose homeostasis; Cell biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00006012526,0.0002881377,0.0003591239,0.0001124955,0.00008729598,0.00003041261,0.0001171614,0.0001572045,0.000003750194],"category_scores_gemma":[0.0002601566,0.0002823284,0.00003671442,0.0001603892,0.0002783153,0.00003365792,0.0001110093,0.0001950235,3.524563e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001282264,"about_ca_system_score_gemma":0.00003636995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001619484,"about_ca_topic_score_gemma":0.00003256199,"domain_scores_codex":[0.9982745,0.0001592686,0.0004059885,0.0006372819,0.0001139311,0.0004090479],"domain_scores_gemma":[0.999328,0.00006403642,0.0001859237,0.0002638065,0.0000687587,0.00008950065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005274473,0.0001312802,0.006240414,0.0001275789,0.00003575334,0.00001190249,0.0001924715,0.00005305467,0.990997,0.0002564276,0.00001610363,0.001410603],"study_design_scores_gemma":[0.001728927,0.0003973873,0.02349004,0.000216314,0.00002814293,0.000009180308,0.0003112128,0.00002401867,0.9728993,0.0005745001,0.00006478167,0.0002562455],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941233,0.004510473,0.00001950483,0.0006926177,0.00003426671,0.0004508786,0.00004808545,0.00001874704,0.0001021643],"genre_scores_gemma":[0.9958794,0.003152827,0.0006376568,0.0001089523,0.00003002721,0.00006531952,0.00006271915,0.00002264015,0.00004045777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01809771,"threshold_uncertainty_score":0.9999629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01089637581867875,"score_gpt":0.234535451560806,"score_spread":0.2236390757421273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}