{"id":"W2129622487","doi":"10.1152/ajprenal.00341.2005","title":"Nitric oxide induces apoptosis in renal tubular epithelial cells through activation of caspase-8","year":2005,"lang":"en","type":"article","venue":"American Journal of Physiology-Renal Physiology","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Apoptosis; Proinflammatory cytokine; TEC; Propidium iodide; Annexin; Caspase 8; Caspase 3; Nitric oxide; Chemistry; Cell biology; Biology; Inflammation; Molecular biology; Programmed cell death; Immunology; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003706377,0.0003428129,0.001508564,0.0005349641,0.00005094575,0.000004157354,0.0003016822,0.0001706947,0.0001099167],"category_scores_gemma":[0.0002084064,0.0002650254,0.0003867325,0.0008547399,0.0006597469,0.0002678314,0.00007147558,0.0008111481,0.00003354572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001441142,"about_ca_system_score_gemma":0.0002632778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003968003,"about_ca_topic_score_gemma":0.000004301029,"domain_scores_codex":[0.9972285,0.0004783134,0.001075799,0.0003663113,0.0003118293,0.0005392431],"domain_scores_gemma":[0.9972125,0.0006367235,0.001358056,0.0003411107,0.0002926608,0.0001589343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002578722,0.000584399,0.0001270236,0.0000493277,0.0002737632,0.00001007971,0.0003191816,0.002098273,0.9871807,0.00004475056,0.000378856,0.006354969],"study_design_scores_gemma":[0.002734741,0.002686175,0.05652901,0.0001779165,0.0001500981,0.00009341183,0.0002936086,0.00007771675,0.935488,0.001007617,0.0005340655,0.0002276364],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988379,0.0001329881,0.0001126722,0.0004569964,0.0001247684,0.000206347,0.00001299719,0.00001604639,0.00009929789],"genre_scores_gemma":[0.9937664,0.000290732,0.003695249,0.001090158,0.001069072,0.000009987421,0.00001420579,0.00003689266,0.00002726096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05640199,"threshold_uncertainty_score":0.9999802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01216349237756628,"score_gpt":0.2664394403425969,"score_spread":0.2542759479650307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}