{"id":"W2129725166","doi":"10.1002/bit.25347","title":"Engineering the oxygen sensing regulation results in an enhanced recombinant human hemoglobin production by <i>Saccharomyces cerevisiae</i>","year":2014,"lang":"en","type":"article","venue":"Biotechnology and Bioengineering","topic":"Hemoglobin structure and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fondation Chalmers; Novo Nordisk Fonden; European Research Council; Knut och Alice Wallenbergs Stiftelse","keywords":"Hemoglobin; Recombinant DNA; Saccharomyces cerevisiae; Escherichia coli; Titer; Yeast; Metabolic engineering; Biochemistry; Blood substitute; Biology; Chemistry; Microbiology; Immunology; Gene; Antibody","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002977515,0.0001660113,0.0001337815,0.00008261384,0.0001051611,0.00002433743,0.0001060457,0.0003483075,8.695952e-7],"category_scores_gemma":[0.00008192268,0.0001365615,0.00002436295,0.0001716187,0.00005492939,0.00001411224,0.00005361874,0.0001769508,0.000001037822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001821069,"about_ca_system_score_gemma":0.000005689988,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001283878,"about_ca_topic_score_gemma":0.00002582961,"domain_scores_codex":[0.9990518,0.00003025013,0.0002254757,0.0004095399,0.00005723472,0.000225699],"domain_scores_gemma":[0.9995631,0.00000769327,0.00006122288,0.0003119063,0.00002349372,0.00003256718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000254674,0.000008195467,0.00005250453,0.00001447656,0.00001208567,2.85079e-7,0.0000254947,0.0005242698,0.9859925,0.0001352223,0.0001820132,0.01302752],"study_design_scores_gemma":[0.0003487892,0.0001816979,0.00158669,0.00003504396,0.00001200784,0.0000316558,0.00003780168,0.002913563,0.9837872,0.00005482851,0.01080837,0.0002022979],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882835,0.0002813361,0.00985755,0.0009742078,0.0003054141,0.0001764892,0.000002951994,0.00008405934,0.00003447914],"genre_scores_gemma":[0.9985763,0.0001096969,0.0009237336,0.00003730929,0.0001796374,0.000006015146,0.00008919938,0.00001757729,0.00006049232],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01282522,"threshold_uncertainty_score":0.5568817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004523649053275804,"score_gpt":0.2011792761642136,"score_spread":0.1966556271109378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}