{"id":"W2129742590","doi":"10.4049/jimmunol.171.8.4187","title":"IFN-γ-Induced MHC Class II Expression: Transactivation of Class II Transactivator Promoter IV by IFN Regulatory Factor-1 is Regulated by Protein Kinase C-α","year":2003,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"","keywords":"CIITA; Transactivation; IRF1; MHC class II; Molecular biology; Protein kinase C; Biology; MHC class I; CD74; Signal transduction; Cell biology; Transcription factor; Major histocompatibility complex; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000176365,0.0004487077,0.0002859917,0.0001966478,0.000169425,0.0003765079,0.0001759126,0.0001685832,0.001217573],"category_scores_gemma":[0.0001008829,0.0001515396,0.0003857062,0.0001829518,0.0002575036,0.0002155158,0.000185771,0.0006543547,0.0006255586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004122869,"about_ca_system_score_gemma":0.0002581181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005382893,"about_ca_topic_score_gemma":0.0005031073,"domain_scores_codex":[0.9998405,0.00001773529,0.00001492812,0.00004267934,0.00003357475,0.0000505958],"domain_scores_gemma":[0.9999126,0.00001087569,0.00003155782,0.00001358883,0.00001391785,0.00001734471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009076689,0.0000127183,0.0001572989,0.00001848997,0.000001957909,0.0000148589,0.000006731004,0.00001655283,0.9993095,0.00003691874,0.00000863792,0.0003256308],"study_design_scores_gemma":[0.00002211841,0.00009371791,0.005859298,0.000009770139,0.00001245899,0.0001478039,0.00002799959,0.0007125167,0.9917107,0.00005833541,0.001342079,0.000003265519],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898901,0.003119563,0.004869914,0.0001200228,0.00006846809,0.00003882273,0.0004071893,0.00006122725,0.001424655],"genre_scores_gemma":[0.991907,0.001362574,0.002672065,0.00005954583,0.00002192412,0.00003994281,0.0008404879,0.00002187934,0.003074603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001217573,"threshold_uncertainty_score":0.004073203,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01681797563311501,"score_gpt":0.24823956921388,"score_spread":0.231421593580765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}