{"id":"W2129768414","doi":"10.1093/carcin/bgl167","title":"Valproate induces widespread epigenetic reprogramming which involves demethylation of specific genes","year":2006,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":256,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"DNA methylation; Epigenetics; Chromatin immunoprecipitation; Reprogramming; Epigenome; Biology; Histone deacetylase inhibitor; Histone deacetylase; Histone; Trichostatin A; Chromatin; Methylated DNA immunoprecipitation; Epigenomics; DNA demethylation; Molecular biology; Acetylation; Cancer research; Gene expression; Gene; Genetics; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008149189,0.0004526982,0.00031189,0.0002538672,0.0001170455,0.000178855,0.0001338861,0.0002149441,0.001093736],"category_scores_gemma":[0.00008701132,0.0001358388,0.0002929226,0.0001415959,0.0002076181,0.00007973016,0.0001981617,0.0003571769,0.0001868818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002400358,"about_ca_system_score_gemma":0.0001178159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003976812,"about_ca_topic_score_gemma":0.0007423565,"domain_scores_codex":[0.9998602,0.00002736501,0.00001144791,0.00004090094,0.00003396432,0.00002613525],"domain_scores_gemma":[0.9999399,0.0000116653,0.00002327067,0.000009403831,0.000005063175,0.00001070752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001783766,0.00002206813,0.0002325425,0.00003113729,0.00001221012,0.00008411503,0.000009735842,0.00005132604,0.9969808,0.00007152502,0.00005338926,0.002272676],"study_design_scores_gemma":[0.00004681306,0.00117776,0.01034994,0.000007803934,0.00002987212,0.0006189272,0.00002181366,0.000465409,0.981576,0.0001255691,0.005574868,0.000005249976],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891789,0.003969267,0.002850021,0.0001463464,0.00008943714,0.00006138835,0.001023449,0.0002506495,0.002430696],"genre_scores_gemma":[0.9931864,0.001969291,0.001424116,0.0001115226,0.00002766007,0.00005193083,0.0009233525,0.0000214377,0.002284252],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001093736,"threshold_uncertainty_score":0.00365895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01859428628367443,"score_gpt":0.2555378533643173,"score_spread":0.2369435670806429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}