{"id":"W2129768414","doi":"10.1093/carcin/bgl167","title":"Valproate induces widespread epigenetic reprogramming which involves demethylation of specific genes","year":2006,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":256,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"DNA methylation; Epigenetics; Chromatin immunoprecipitation; Reprogramming; Epigenome; Biology; Histone deacetylase inhibitor; Histone deacetylase; Histone; Trichostatin A; Chromatin; Methylated DNA immunoprecipitation; Epigenomics; DNA demethylation; Molecular biology; Acetylation; Cancer research; Gene expression; Gene; Genetics; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004717731,0.0002188584,0.0002485431,0.0001727883,0.0001242595,0.00002880392,0.0002690379,0.0002251374,0.00002049553],"category_scores_gemma":[0.0001309942,0.0002269768,0.000144188,0.0004648146,0.0001615714,0.000007230649,0.0001292993,0.00008262484,0.00001671188],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004253155,"about_ca_system_score_gemma":0.0001387283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003293209,"about_ca_topic_score_gemma":0.0002267876,"domain_scores_codex":[0.9980079,0.0001719845,0.0004576331,0.0005916325,0.0003463299,0.0004245366],"domain_scores_gemma":[0.9986312,0.00003808098,0.0001673192,0.0006621453,0.0004059613,0.00009533393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000442711,0.00006905467,0.02662175,0.00005023626,0.00002978537,0.000003471783,0.00004082447,0.0004033634,0.9599173,0.00003541839,0.0006426584,0.01214185],"study_design_scores_gemma":[0.0002673597,0.0001392042,0.02347334,0.00002041948,0.000022621,0.000007088781,0.00006358519,0.00002778051,0.9656254,0.00005793234,0.01006854,0.0002266948],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825848,0.01500802,0.001206046,0.00004616379,0.0001742483,0.0003011226,0.00001699382,0.00002368366,0.0006389719],"genre_scores_gemma":[0.9956343,0.0005039424,0.0026289,0.000009434219,0.0005107477,0.00005855143,0.0001835908,0.00005193686,0.0004186403],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01450408,"threshold_uncertainty_score":0.9255845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01859428628367443,"score_gpt":0.2555378533643173,"score_spread":0.2369435670806429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}