{"id":"W2129784359","doi":"10.1186/1743-422x-4-57","title":"HIV-1 Vpr activates the G2 checkpoint through manipulation of the ubiquitin proteasome system","year":2007,"lang":"en","type":"article","venue":"Virology Journal","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":152,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Conselho Nacional de Desenvolvimento Científico e Tecnológico; York University; National Institute of General Medical Sciences; Saint Louis University","keywords":"Ubiquitin ligase; Biology; Cullin; Cell biology; Ubiquitin; Proteasome; DDB1; Mutant; Protein subunit; Molecular biology; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001196119,0.0001512963,0.0001610061,0.00002963044,0.0003164629,0.00002059829,0.0004182566,0.0002203617,0.00003620155],"category_scores_gemma":[0.0001059485,0.00008472317,0.0001742385,0.00009675024,0.0002084129,0.000008052903,0.0001454413,0.000378241,0.00001260914],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003003997,"about_ca_system_score_gemma":0.00007240446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008786468,"about_ca_topic_score_gemma":0.000008577449,"domain_scores_codex":[0.9986435,0.0002552883,0.0004091398,0.0001823251,0.0001856826,0.0003240457],"domain_scores_gemma":[0.9990417,0.00003624347,0.0004152794,0.0003541561,0.000101758,0.00005088591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002208396,0.00003983168,0.004766906,0.00002879395,0.0000737037,0.000006086529,0.0002548787,0.00006751317,0.9914365,0.002021369,0.0003447217,0.000738891],"study_design_scores_gemma":[0.0005026,0.0002241878,0.02469275,0.00003960755,0.00002943196,0.0009445172,0.0004339899,0.00003733258,0.9631799,0.0006988548,0.009105226,0.0001116042],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988501,0.0005219278,0.005513401,0.001176746,0.0003553662,0.0003745685,0.000008919853,0.00001038175,0.003537735],"genre_scores_gemma":[0.9982383,0.00003725113,0.0003915119,0.0003396238,0.0007022926,0.00001383789,0.000006917065,0.00001937089,0.0002509369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02825657,"threshold_uncertainty_score":0.3454911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01570272955712938,"score_gpt":0.2461526474387722,"score_spread":0.2304499178816428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}