{"id":"W2129784373","doi":"10.1242/dev.00478","title":"Elevated SMAD1/β-catenin molecular complexes and renal medullary cystic dysplasia in ALK3 transgenic mice","year":2003,"lang":"en","type":"article","venue":"Development","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"","keywords":"Biology; Wnt signaling pathway; Renal dysplasia; Dysplasia; Kidney; Mesenchyme; Genetically modified mouse; Cancer research; Pathology; Transgene; Cell biology; Endocrinology; Signal transduction; Genetics; Gene; Mesenchymal stem cell; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001583204,0.0001732998,0.0001495825,0.00006225511,0.00005519446,0.00001362613,0.00009448153,0.0001508631,0.00001872809],"category_scores_gemma":[0.00001895972,0.0001548996,0.00003352835,0.0001373473,0.00005818041,0.000002474193,0.00002408246,0.0001139011,0.00001006108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003443449,"about_ca_system_score_gemma":0.0001872692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001220554,"about_ca_topic_score_gemma":0.00003934839,"domain_scores_codex":[0.9989475,0.00007145848,0.00025321,0.0003275982,0.0001214979,0.0002787348],"domain_scores_gemma":[0.9997217,0.000007160271,0.00004177829,0.0001033136,0.00003091256,0.00009513308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006413693,0.00003415467,0.0007171608,0.00002652461,0.0001000854,0.0000268679,0.0001594835,0.0001815275,0.9971141,0.0001104731,0.0002068651,0.001258677],"study_design_scores_gemma":[0.0009976104,0.00006776259,0.005342917,0.00004985009,0.00001673138,0.00007135278,0.00005280668,0.00001886926,0.955092,0.00008178603,0.03793103,0.0002772811],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955561,0.002353956,0.0008760339,0.00008833623,0.00009502153,0.0001592215,0.000003005756,0.00000968949,0.0008586484],"genre_scores_gemma":[0.996004,0.0003594635,0.002949563,0.0002078621,0.00001392273,0.00002867467,0.00009675885,0.0000185573,0.0003211293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04202204,"threshold_uncertainty_score":0.6316621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006059048964081175,"score_gpt":0.2110498364685782,"score_spread":0.204990787504497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}