{"id":"W2129800911","doi":"10.1016/j.cardfail.2004.05.006","title":"Clinical effects of endothelin receptor antagonism with bosentan in patients with severe chronic heart failure: results of a pilot study","year":2005,"lang":"en","type":"article","venue":"Journal of Cardiac Failure","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":272,"is_retracted":false,"has_abstract":false,"ca_institutions":"London Health Sciences Centre","funders":"","keywords":"Bosentan; Medicine; Heart failure; Endothelin receptor antagonist; Endothelin receptor; Placebo; Internal medicine; Cardiology; Ejection fraction; Adverse effect; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002528817,0.001601718,0.003311697,0.0002732625,0.000920371,0.0007699215,0.0006496481,0.001350278,0.002199091],"category_scores_gemma":[0.003315618,0.0005393141,0.00153011,0.000413309,0.001836765,0.001519506,0.000497199,0.002672709,0.0004590932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004474249,"about_ca_system_score_gemma":0.001117335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009758217,"about_ca_topic_score_gemma":0.001102243,"domain_scores_codex":[0.9988795,0.0006068198,0.00008802099,0.0001234417,0.0001042389,0.0001980508],"domain_scores_gemma":[0.9968125,0.001246909,0.0002666138,0.0002782325,0.0001575789,0.001238138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8203207,0.07862125,0.02533137,0.0003626611,0.0008535761,0.001030219,0.000704291,0.000727394,0.02678572,0.0001251983,0.0007025287,0.0444351],"study_design_scores_gemma":[0.1398299,0.7656504,0.09047341,0.00002139297,0.0005119509,0.0003237445,0.0002368141,0.0004907981,0.001678275,0.00007670673,0.0006620437,0.00004468329],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981428,0.0004916482,0.0001387491,0.0001147903,0.00004125132,0.0003150571,0.000127072,0.00001090633,0.0006176894],"genre_scores_gemma":[0.9974779,0.0005503704,0.0003989945,0.0002609381,0.0002636313,0.0003627783,0.0003066365,0.000007230957,0.000371449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003311697,"threshold_uncertainty_score":0.01337379,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007891862098557623,"score_gpt":0.264206612929706,"score_spread":0.2563147508311484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}