{"id":"W2129805561","doi":"10.1200/jco.2013.49.3007","title":"Do<i>BRCA1</i>and<i>BRCA2</i>Mutation Carriers Have Earlier Natural Menopause Than Their Noncarrier Relatives? Results From the Kathleen Cuningham Foundation Consortium for Research Into Familial Breast Cancer","year":2013,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ste. Anne's Hospital","funders":"","keywords":"Medicine; Ovarian cancer; BRCA mutation; Breast cancer; Proportional hazards model; Hazard ratio; Oophorectomy; Internal medicine; Germline mutation; Mutation; Gynecology; Cohort; Cancer; Oncology; Obstetrics; Genetics; Surgery; Hysterectomy; Confidence interval; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002469752,0.0001742964,0.0002038969,0.0005316548,0.0002312591,0.0003131853,0.0004071927,0.0002448929,0.002632435],"category_scores_gemma":[0.008760646,0.0001210246,0.0004690523,0.0004051729,0.0002548538,0.000257295,0.000246367,0.0002177702,0.0001457306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003003846,"about_ca_system_score_gemma":0.0003393437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01922623,"about_ca_topic_score_gemma":0.01832655,"domain_scores_codex":[0.9993518,0.0002632082,0.00004214642,0.00014232,0.000135696,0.00006485452],"domain_scores_gemma":[0.9934007,0.003367167,0.002065049,0.0003350716,0.000487898,0.0003440893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005889615,0.00001655336,0.9917499,0.00006901346,0.0001133461,0.00008395802,0.000179693,0.00006558686,0.0001019448,0.00005459284,0.0004781597,0.006498235],"study_design_scores_gemma":[0.00002135701,0.00007243577,0.9986448,0.00002860166,0.0001200131,0.0001786627,0.0001254831,0.0001317261,0.00004891607,0.00006543246,0.000558736,0.000004025132],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938333,0.002542338,0.0002014343,0.0003319738,0.00001868993,0.00001498719,0.0009662403,0.000005342328,0.002085608],"genre_scores_gemma":[0.9987748,0.0004418082,0.00007289199,0.00008181395,0.00001656273,0.000006483844,0.0004117194,0.00000197757,0.0001919093],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01922623,"threshold_uncertainty_score":0.03822863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08474180481747456,"score_gpt":0.4465159024221214,"score_spread":0.3617740976046468,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}