{"id":"W2129806338","doi":"10.4049/jimmunol.178.2.798","title":"IL-10 Regulation by HIV-Tat in Primary Human Monocytic Cells: Involvement of Calmodulin/Calmodulin-Dependent Protein Kinase-Activated p38 MAPK and Sp-1 and CREB-1 Transcription Factors","year":2007,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Children's Hospital of Eastern Ontario; University of Ottawa","funders":"","keywords":"CREB; Calmodulin; p38 mitogen-activated protein kinases; Protein kinase A; Cell biology; Transcription factor; MAPK/ERK pathway; Kinase; Biology; Chemistry; Gene; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001642227,0.0003400622,0.0003253232,0.0001904206,0.0002927523,0.0003319998,0.0001115894,0.0002336918,0.001628566],"category_scores_gemma":[0.0001052115,0.0002015711,0.0003393943,0.0002268278,0.000234942,0.0001455135,0.0001491674,0.0005750892,0.0004713543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003964187,"about_ca_system_score_gemma":0.0003825874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003080353,"about_ca_topic_score_gemma":0.004719258,"domain_scores_codex":[0.99983,0.00002729941,0.00001497507,0.00002606521,0.00003556758,0.00006604742],"domain_scores_gemma":[0.9999194,0.00002199302,0.00001053477,0.000009638986,0.00001564466,0.00002280327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002862208,0.00005294971,0.0002900164,0.00007886301,0.000003754727,0.0001382853,0.00005552767,0.00003455184,0.9981389,0.00004672724,0.00006264746,0.0008114384],"study_design_scores_gemma":[0.000109758,0.0005267584,0.02053734,0.00002203576,0.0000338627,0.000403564,0.0001466044,0.001377649,0.9742312,0.0001122035,0.002486787,0.00001227753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883052,0.005151292,0.003211474,0.0002660627,0.0001470227,0.00009319058,0.001394953,0.00006358336,0.001367189],"genre_scores_gemma":[0.9881896,0.002923819,0.004472127,0.0001505562,0.00004943664,0.0001534545,0.001233526,0.00000976434,0.002817591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003080353,"threshold_uncertainty_score":0.006124854,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01305862386730505,"score_gpt":0.2197420774013367,"score_spread":0.2066834535340317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}