{"id":"W2129848727","doi":"10.1038/npp.2015.337","title":"Enzymatic Depletion of the Polysialic Acid Moiety Associated with the Neural Cell Adhesion Molecule Inhibits Antidepressant Efficacy","year":2015,"lang":"en","type":"article","venue":"Neuropsychopharmacology","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of British Columbia","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Neurogenesis; Polysialic acid; Antidepressant; Neural cell adhesion molecule; Neuroplasticity; Neuroscience; Neurotrophic factors; Synaptic plasticity; Hippocampal formation; Pharmacology; Psychology; Hippocampus; Medicine; Chemistry; Internal medicine; Receptor; Cell adhesion; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002083365,0.0002342013,0.0002523429,0.00006758685,0.0001990663,0.00002958788,0.0007108585,0.00008679803,0.00003766587],"category_scores_gemma":[0.0004460727,0.0001303195,0.0001446849,0.0008196789,0.0004040144,0.0001023636,0.0001535711,0.0004237518,0.00002493696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002526555,"about_ca_system_score_gemma":0.00006124702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001023066,"about_ca_topic_score_gemma":0.000005671688,"domain_scores_codex":[0.9970683,0.001265174,0.0002990282,0.0004643778,0.0005066067,0.0003964762],"domain_scores_gemma":[0.9986352,0.0003973676,0.0003263033,0.0004496827,0.00007670087,0.0001147047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002848115,0.0003708852,0.000424794,0.000009853661,0.00001110635,0.00001474184,0.000397449,0.0006208759,0.992086,0.00002420958,0.005405806,0.0003494797],"study_design_scores_gemma":[0.004409598,0.0004049949,0.02190883,0.00001407609,0.000056541,0.00002741836,0.00008508196,0.001469389,0.9708194,0.00002926046,0.0005975992,0.0001778436],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949786,0.0001374858,0.00002650439,0.002111234,0.0007551439,0.0006635857,0.00001068178,0.00008964863,0.001227139],"genre_scores_gemma":[0.9939352,0.00002345181,0.000005961855,0.005756909,0.00005599285,0.0000273095,0.000001643421,0.00003932592,0.0001542569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02148404,"threshold_uncertainty_score":0.5314277,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02847710305019133,"score_gpt":0.2735731358607056,"score_spread":0.2450960328105143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}