{"id":"W2129887231","doi":"10.1093/carcin/bgn186","title":"Synergistic effects of Pten loss and WNT/CTNNB1 signaling pathway activation in ovarian granulosa cell tumor development and progression","year":2008,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cegep de Saint Hyacinthe; McGill University; Hôpital Maisonneuve-Rosemont; McGill University Health Centre; Université de Montréal","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","keywords":"PTEN; PI3K/AKT/mTOR pathway; Protein kinase B; Wnt signaling pathway; Cancer research; Biology; Signal transduction; Endocrinology; Cell biology; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003148372,0.0002459979,0.0004183705,0.0004706936,0.0001551043,0.0004163734,0.0001544301,0.0002822904,0.001245044],"category_scores_gemma":[0.0002096937,0.0001979846,0.0002857036,0.0002028223,0.0002903302,0.000225521,0.0004524077,0.0005037023,0.0001805835],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003305871,"about_ca_system_score_gemma":0.0004488741,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000972751,"about_ca_topic_score_gemma":0.002338623,"domain_scores_codex":[0.999683,0.00005325706,0.00002808479,0.00005651371,0.00009111856,0.00008790482],"domain_scores_gemma":[0.9998165,0.00002354701,0.00004036326,0.00001959083,0.00001149694,0.00008860813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001281713,0.0001652957,0.005216541,0.0001107785,0.00003236078,0.0005424875,0.00005351209,0.000333926,0.9843094,0.0002904998,0.0001806312,0.007482787],"study_design_scores_gemma":[0.0001409106,0.002572096,0.06473202,0.00002291899,0.0001224783,0.002333076,0.0002475721,0.00333952,0.9191488,0.0002625146,0.00706035,0.00001769168],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957345,0.002165721,0.0006340038,0.00008675421,0.00002425526,0.00003513872,0.0001813937,0.00004678205,0.001091516],"genre_scores_gemma":[0.9979576,0.0005746103,0.0004093108,0.0000368182,0.000005087304,0.00003149522,0.0001620228,0.000005131504,0.0008179256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001245044,"threshold_uncertainty_score":0.004165113,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009192265643310181,"score_gpt":0.2186120156027448,"score_spread":0.2094197499594347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}