{"id":"W2129887231","doi":"10.1093/carcin/bgn186","title":"Synergistic effects of Pten loss and WNT/CTNNB1 signaling pathway activation in ovarian granulosa cell tumor development and progression","year":2008,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cegep de Saint Hyacinthe; McGill University; Hôpital Maisonneuve-Rosemont; McGill University Health Centre; Université de Montréal","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","keywords":"PTEN; PI3K/AKT/mTOR pathway; Protein kinase B; Wnt signaling pathway; Cancer research; Biology; Signal transduction; Endocrinology; Cell biology; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001414311,0.0001696083,0.0001983635,0.00007990235,0.00008665206,0.000007702997,0.00008216764,0.0001011989,0.000002219293],"category_scores_gemma":[0.00006956876,0.0001616975,0.00003054987,0.0001087653,0.0001022036,0.000005705813,0.00007880248,0.000054967,4.830572e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003123427,"about_ca_system_score_gemma":0.0001424619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000321786,"about_ca_topic_score_gemma":0.000006606065,"domain_scores_codex":[0.9989887,0.00006938696,0.0002345127,0.0003579365,0.0001465195,0.0002028848],"domain_scores_gemma":[0.999533,0.00004692779,0.0001209781,0.000155299,0.00006672057,0.00007708007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006997776,0.00004780291,0.05745202,0.0002899438,0.00001611266,0.00003359692,0.0002540026,0.00003472425,0.939832,0.000006142045,0.000008411273,0.001955273],"study_design_scores_gemma":[0.0007188172,0.0001162508,0.03709843,0.0001422822,0.00001436543,0.00001134887,0.00002936838,0.00002367253,0.9615433,0.00001142814,0.0001067233,0.0001839898],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996433,0.002305054,0.0008997092,0.00001139395,0.00006142838,0.0002434656,0.00000349903,0.00000733515,0.00003508624],"genre_scores_gemma":[0.9984362,0.00006395051,0.001257226,0.00003989803,0.00006684146,0.00005753558,0.00002886562,0.00002424686,0.00002525849],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02171132,"threshold_uncertainty_score":0.6593831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009192265643310181,"score_gpt":0.2186120156027448,"score_spread":0.2094197499594347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}