{"id":"W2129914802","doi":"10.1016/j.pbb.2008.09.016","title":"Mutant mice with reduced NMDA-NR1 glycine affinity or lack of d-amino acid oxidase function exhibit altered anxiety-like behaviors","year":2008,"lang":"en","type":"article","venue":"Pharmacology Biochemistry and Behavior","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto; Canada Research Chairs","funders":"Canadian Institutes of Health Research; National Alliance for Research on Schizophrenia and Depression; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; F. Hoffmann-La Roche","keywords":"Glycine; NMDA receptor; Anxiogenic; Mutant; Anxiolytic; Serine; Open field; Elevated plus maze; Anxiety; Biochemistry; Chemistry; Amino acid; Receptor; Biology; Pharmacology; Endocrinology; Psychology; Enzyme; Gene; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003188036,0.002233129,0.0008308293,0.002161391,0.0005009374,0.0007758611,0.0009115774,0.001599143,0.007722626],"category_scores_gemma":[0.0004919722,0.0006203824,0.0007484401,0.0004987543,0.001403133,0.0006536598,0.0006622754,0.002385781,0.001701096],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007603879,"about_ca_system_score_gemma":0.0004523933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00203853,"about_ca_topic_score_gemma":0.003498654,"domain_scores_codex":[0.9993718,0.0000525865,0.00009966647,0.0001944757,0.0001743484,0.0001070977],"domain_scores_gemma":[0.9985043,0.0001558908,0.000685138,0.00008543151,0.00007863686,0.0004906239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000296281,0.00006767954,0.0002621895,0.00002778254,0.00002638516,0.0002614611,0.00004148158,0.00009963164,0.9976763,0.0003698804,0.0001193259,0.0007515483],"study_design_scores_gemma":[0.0002419451,0.000513592,0.01227148,0.0000489001,0.0001762118,0.003433382,0.0002192284,0.002241788,0.9770193,0.0006301679,0.003141918,0.00006229054],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9809412,0.0006534131,0.01011693,0.0005669782,0.0002619018,0.00007244838,0.003767228,0.001083335,0.002536491],"genre_scores_gemma":[0.9614776,0.0009820695,0.01211052,0.0003731398,0.00009821816,0.0002149097,0.002878744,0.001005958,0.02085874],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007722626,"threshold_uncertainty_score":0.02583474,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02674805373741901,"score_gpt":0.2934171164926755,"score_spread":0.2666690627552565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}