{"id":"W2129931005","doi":"10.1200/jco.2007.13.4452","title":"Phase III Randomized, Intergroup Trial Assessing Imatinib Mesylate At Two Dose Levels in Patients With Unresectable or Metastatic Gastrointestinal Stromal Tumors Expressing the Kit Receptor Tyrosine Kinase: S0033","year":2008,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Gastrointestinal Tumor Research and Treatment","field":"Medicine","cited_by":1077,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; U.S. Public Health Service","keywords":"Medicine; Imatinib mesylate; Imatinib; GiST; Regimen; Internal medicine; Surgery; Oncology; Phases of clinical research; Clinical trial; Gastroenterology; Tyrosine-kinase inhibitor; Progression-free survival; Chemotherapy; Stromal cell; Cancer","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001663125,0.001588627,0.002024617,0.0004112576,0.0004353848,0.001094348,0.0008188554,0.00158542,0.005802337],"category_scores_gemma":[0.001646822,0.0004814245,0.001316958,0.0004943925,0.001214101,0.0008656766,0.0004173792,0.002877357,0.0008477087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009948981,"about_ca_system_score_gemma":0.002166566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001577708,"about_ca_topic_score_gemma":0.00424394,"domain_scores_codex":[0.9993035,0.0004308832,0.00003280364,0.00008147726,0.0000507363,0.0001006914],"domain_scores_gemma":[0.998753,0.0003203033,0.0002725941,0.00006946626,0.00005994331,0.0005246942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9713538,0.01093209,0.001323562,0.0001715381,0.0004393465,0.00004502247,0.00006256959,0.0004426657,0.003791663,0.00009857586,0.0009772053,0.01036191],"study_design_scores_gemma":[0.9426228,0.05468228,0.001485869,0.000009147942,0.0001313398,0.00002149878,0.00001677443,0.0003593803,0.0003296468,0.00008108497,0.0002516846,0.00000846634],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939905,0.0009038607,0.0004249306,0.0005913379,0.0001954331,0.002017138,0.0007065029,0.00007769102,0.00109258],"genre_scores_gemma":[0.9890941,0.0009008057,0.001514836,0.001237034,0.0002586736,0.003623623,0.001456442,0.00002568088,0.001888801],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005802337,"threshold_uncertainty_score":0.01941073,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1692056531082675,"score_gpt":0.4733452979920085,"score_spread":0.304139644883741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}