{"id":"W2129944198","doi":"10.1158/1535-7163.mct-14-1078","title":"AMG 595, an Anti-EGFRvIII Antibody–Drug Conjugate, Induces Potent Antitumor Activity against EGFRvIII-Expressing Glioblastoma","year":2015,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"Arbutus Biopharma (Canada)","funders":"","keywords":"Cancer research; Antibody-drug conjugate; Epidermal growth factor receptor; Antibody; Conjugate; Chemistry; Monoclonal antibody; Molecular biology; Medicine; Receptor; Biology; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002568735,0.0005288502,0.0007196782,0.0002252193,0.0002004985,0.0001685119,0.0002576331,0.0001752254,0.00002701887],"category_scores_gemma":[0.00001565444,0.0004510945,0.0002326427,0.0004470174,0.0001915029,0.0002867019,0.0001105481,0.0003638708,0.00003388565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003244163,"about_ca_system_score_gemma":0.0004380126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004046272,"about_ca_topic_score_gemma":0.00006873353,"domain_scores_codex":[0.9972202,0.0001979129,0.0003809482,0.000721744,0.0007990762,0.0006801857],"domain_scores_gemma":[0.9979835,0.00002890257,0.0002514275,0.0008328203,0.0003625659,0.0005408023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004042981,0.0017423,0.01885375,0.00007126494,0.0007152296,0.001473526,0.0007354231,0.0004333607,0.9445757,0.0000697734,0.0001278907,0.03079746],"study_design_scores_gemma":[0.00527082,0.0007682018,0.02558823,0.0003938384,0.0006759553,0.0001023967,0.0003430896,0.00153837,0.9565059,0.0000807444,0.008111664,0.0006207995],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901453,0.005319033,0.0002801139,0.001929955,0.0005442391,0.0006914506,0.00005656218,0.0001788895,0.0008544155],"genre_scores_gemma":[0.9949281,0.0008099709,0.0005058377,0.003216288,0.0002317063,0.00007832728,0.00006312216,0.0001180495,0.00004862607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03017666,"threshold_uncertainty_score":0.9997941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04084305897425566,"score_gpt":0.3333669018782425,"score_spread":0.2925238429039868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}