{"id":"W2129961545","doi":"10.1158/0008-5472.can-05-4230","title":"Transgenic Mice Expressing the p75 CCAAT-Displacement Protein/Cut Homeobox Isoform Develop a Myeloproliferative Disease–Like Myeloid Leukemia","year":2006,"lang":"en","type":"article","venue":"Cancer Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; Université de Montréal; Immunovaccine (Canada); McGill University","funders":"Canadian Breast Cancer Research Alliance; Genome Canada; U.S. Department of Defense","keywords":"Biology; Genetically modified mouse; Myeloid; Haematopoiesis; Transgene; Myeloproliferative neoplasm; Cancer research; Bone marrow; Leukemia; Myeloproliferative Disorders; Molecular biology; Immunology; Pathology; Stem cell; Cell biology; Myelofibrosis; Medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001594795,0.0003574051,0.0002460416,0.0001713535,0.0009430043,0.0002227989,0.001028131,0.000187132,0.0002541627],"category_scores_gemma":[0.00009497412,0.0002721736,0.0001484527,0.0007573871,0.0006672518,0.00002110529,0.00034073,0.0006983281,0.00006913993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006147329,"about_ca_system_score_gemma":0.003569499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004704927,"about_ca_topic_score_gemma":0.002205807,"domain_scores_codex":[0.9954242,0.0006441748,0.0003982986,0.0009053567,0.001267645,0.001360286],"domain_scores_gemma":[0.9979106,0.00006284669,0.00008042477,0.000894036,0.0007440328,0.0003080904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004950383,0.00009278352,0.0002820916,0.0001039567,0.0001193768,0.00000943224,0.0002783206,0.0004215128,0.9774857,0.00007229747,0.01021365,0.005970534],"study_design_scores_gemma":[0.001403322,0.0007341757,0.0009894808,0.0001254829,0.00001424083,0.000003283079,0.0002681885,0.0001237224,0.9103786,0.0002703144,0.08526919,0.0004199733],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987215,0.006796119,0.0004318676,0.002041272,0.0001025147,0.002049003,0.0001025443,0.00003171061,0.001229914],"genre_scores_gemma":[0.9835296,0.000737227,0.0001351349,0.0002642644,0.001099484,0.002782203,0.0001747593,0.00009981755,0.01117754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07505553,"threshold_uncertainty_score":0.9999731,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03405168369609882,"score_gpt":0.347724115656607,"score_spread":0.3136724319605082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}