{"id":"W2129995088","doi":"10.1002/mrd.1003","title":"Germ cell specific promoter drives ectopic transgene expression during embryogenesis","year":2001,"lang":"en","type":"article","venue":"Molecular Reproduction and Development","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; National Institute of General Medical Sciences; Medical Research Council Canada","keywords":"Biology; Transgene; Cre recombinase; Ectopic expression; Germ cell; Gene; Genetically modified mouse; Promoter; Gene expression; Molecular biology; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002076326,0.0001871898,0.0001307333,0.00009227316,0.000184414,0.00004197747,0.0001128177,0.0001013435,0.00006078067],"category_scores_gemma":[0.00001263401,0.0001770913,0.00004921157,0.0001062107,0.00004670949,0.000006895111,0.0001174875,0.00007917574,0.00002852394],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000268732,"about_ca_system_score_gemma":0.00005669409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000186279,"about_ca_topic_score_gemma":0.000001106074,"domain_scores_codex":[0.9982997,0.00007724941,0.0002444512,0.0008310076,0.0002523038,0.000295252],"domain_scores_gemma":[0.9992924,0.000001709465,0.00005616577,0.0004609959,0.00006941757,0.0001193329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007964268,0.00008692669,0.001879851,0.00004836247,0.00001933993,0.00004035965,0.0001189072,0.00004169407,0.9906422,0.000001080818,0.0001730336,0.006868544],"study_design_scores_gemma":[0.0004674135,0.00004082874,0.01191575,0.00001267032,0.000003074279,0.00009808929,0.00003951442,0.000001875457,0.8846811,0.000003797369,0.1025322,0.0002037102],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991484,0.003075048,0.004076355,0.0001953116,0.0001349586,0.0003164943,7.625123e-7,0.00002709217,0.0006899133],"genre_scores_gemma":[0.9873007,0.00140193,0.003816821,0.0000359188,0.0001318504,0.00005188534,0.00005146255,0.00003216461,0.007177255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1059611,"threshold_uncertainty_score":0.7221573,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0130097981612624,"score_gpt":0.232484162399916,"score_spread":0.2194743642386536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}