{"id":"W2129995088","doi":"10.1002/mrd.1003","title":"Germ cell specific promoter drives ectopic transgene expression during embryogenesis","year":2001,"lang":"en","type":"article","venue":"Molecular Reproduction and Development","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; National Institute of General Medical Sciences; Medical Research Council Canada","keywords":"Biology; Transgene; Cre recombinase; Ectopic expression; Germ cell; Gene; Genetically modified mouse; Promoter; Gene expression; Molecular biology; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003193314,0.000304236,0.0002865731,0.0002618284,0.0001408429,0.0003601323,0.0004787139,0.0003749845,0.001209904],"category_scores_gemma":[0.0001804023,0.0002918421,0.0002294643,0.0001871148,0.0002659908,0.0002680434,0.0004503244,0.0006954246,0.001347408],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002530502,"about_ca_system_score_gemma":0.0003429104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002928251,"about_ca_topic_score_gemma":0.0006307846,"domain_scores_codex":[0.9997763,0.00002763798,0.00002487738,0.00006131532,0.00007819467,0.00003160481],"domain_scores_gemma":[0.9998133,0.00004207201,0.00004780532,0.00003662688,0.00002163237,0.00003871784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001971535,0.000004599082,0.00009319084,0.00003414465,0.000001961289,0.000057049,0.00001820437,0.00004915639,0.9982238,0.0001921946,0.00003815008,0.001267768],"study_design_scores_gemma":[0.0000172316,0.00007909787,0.001574386,0.00001638151,0.00001712005,0.0005512406,0.0000227043,0.0008876238,0.9852326,0.00009971293,0.01149534,0.000006593581],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7635609,0.006222945,0.2150019,0.0004216128,0.0002892248,0.0003856638,0.002982379,0.001654018,0.009481341],"genre_scores_gemma":[0.8875993,0.004717012,0.08629526,0.0002522104,0.00004953925,0.0002137133,0.003141087,0.0005625475,0.01716929],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001209904,"threshold_uncertainty_score":0.004047573,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0130097981612624,"score_gpt":0.232484162399916,"score_spread":0.2194743642386536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}