{"id":"W2130000639","doi":"10.1189/jlb.0713401","title":"Stem cell factor induces AP-1-dependent mast cell IL-6 production via MAPK kinase 3 activity","year":2014,"lang":"en","type":"article","venue":"Journal of Leukocyte Biology","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Beatrice Hunter Cancer Research Institute; Dalhousie University","funders":"Canadian Institutes of Health Research; Beatrice Hunter Cancer Research Institute","keywords":"Stem cell factor; Cell biology; Mast cell; Biology; NFAT; Transcription factor; Signal transduction; Interleukin 33; p38 mitogen-activated protein kinases; Cytokine; MAPK/ERK pathway; Immunology; Interleukin; Stem cell; Gene; Biochemistry; Haematopoiesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001383614,0.0005207465,0.0002410721,0.0003019434,0.0001114904,0.0002214424,0.000144976,0.000165039,0.001320222],"category_scores_gemma":[0.000119603,0.0001478089,0.0004517977,0.000213512,0.0002474177,0.0001689939,0.0002149976,0.0006778626,0.0003996735],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002424623,"about_ca_system_score_gemma":0.0001808878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002722839,"about_ca_topic_score_gemma":0.000435012,"domain_scores_codex":[0.9998456,0.00002197425,0.0000176777,0.00002869423,0.00004480187,0.00004123442],"domain_scores_gemma":[0.9998966,0.00001561935,0.00003501288,0.00001065365,0.00001178235,0.00003025163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002865656,0.00003790547,0.0001712049,0.00008161007,0.000006521901,0.00006821027,0.00002029108,0.00003805971,0.9980556,0.00006047049,0.00005246217,0.001121172],"study_design_scores_gemma":[0.00007643644,0.000538994,0.008284099,0.00001138402,0.00003450304,0.000340569,0.0000358055,0.001118969,0.9868076,0.0001472117,0.002598343,0.000006091961],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910111,0.002828437,0.003545224,0.0001521243,0.00007351839,0.00006676431,0.0008055644,0.0001627998,0.001354457],"genre_scores_gemma":[0.9924147,0.001385027,0.00300112,0.00009303571,0.00002847812,0.00008680031,0.001266032,0.00002044653,0.001704471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001320222,"threshold_uncertainty_score":0.004416525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01490077872721171,"score_gpt":0.2216323711880026,"score_spread":0.2067315924607908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}