{"id":"W2130060675","doi":"10.1152/ajpregu.00441.2010","title":"Regulation of hepatic cholesterol biosynthesis by berberine during hyperhomocysteinemia","year":2010,"lang":"en","type":"article","venue":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","topic":"Berberine and alkaloids research","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Agriculture and Agri-Food Canada; University of Manitoba; St. Boniface Hospital","funders":"Canadian Institutes of Health Research","keywords":"Hyperhomocysteinemia; HMG-CoA reductase; Berberine; Reductase; Internal medicine; Endocrinology; Methionine; Cholesterol; 7-Dehydrocholesterol reductase; Biosynthesis; Homocysteine; Hydroxymethylglutaryl-CoA reductase; Coenzyme A; Biology; Biochemistry; Chemistry; Enzyme; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001093632,0.0002812931,0.0004665413,0.0002337285,0.0001441088,0.0002051315,0.0001328912,0.0003192386,0.0006914206],"category_scores_gemma":[0.0001413142,0.0001375783,0.0001884906,0.0001234832,0.0002466713,0.0002671685,0.0001481674,0.000392167,0.0001444856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003007055,"about_ca_system_score_gemma":0.000154352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005331417,"about_ca_topic_score_gemma":0.0009640245,"domain_scores_codex":[0.9999197,0.00002126531,0.000006895037,0.00002074088,0.0000112308,0.00002022332],"domain_scores_gemma":[0.9998852,0.00001809973,0.00003936018,0.000009856829,0.00001455809,0.00003289356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009923895,0.00004100581,0.0002283949,0.00004917667,0.000006943515,0.00008191012,0.00002421568,0.00001920645,0.997502,0.0000244395,0.00001872908,0.001011579],"study_design_scores_gemma":[0.0001138797,0.001213732,0.02439635,0.00001292393,0.0000475185,0.0003733063,0.00006906645,0.0006301251,0.9715154,0.00008144531,0.001533197,0.00001308738],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955279,0.003052544,0.0006771893,0.0000850332,0.00002090628,0.00001564038,0.00006607113,0.00003888013,0.0005157492],"genre_scores_gemma":[0.9963914,0.001220096,0.0009226601,0.0000508669,0.0000143443,0.00002239832,0.0001328493,0.000009684944,0.00123581],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006914206,"threshold_uncertainty_score":0.002313018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01391480926319997,"score_gpt":0.2903225352613188,"score_spread":0.2764077259981189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}