{"id":"W2130071233","doi":"10.1001/archneurol.2011.53","title":"Genetic and Clinical Features of Progranulin-Associated Frontotemporal Lobar Degeneration","year":2011,"lang":"en","type":"article","venue":"Archives of Neurology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":121,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute on Aging; National Health and Medical Research Council; Medical Research Council; Canadian Institutes of Health Research; Arizona Biomedical Research Commission; Vlaamse regering; National Center for Research Resources; Fonds Wetenschappelijk Onderzoek; Deutsche Forschungsgemeinschaft; Belgian Federal Science Policy Office; Eusko Jaurlaritza; Arizona Department of Health Services; Wellcome Trust; National Institute of Neurological Disorders and Stroke; Bundesministerium für Bildung und Forschung; Bijzonder Onderzoeksfonds UGent; National Institutes of Health; Universiteit Antwerpen; U.S. Department of Veterans Affairs","keywords":"Frontotemporal lobar degeneration; Frontotemporal dementia; Mutation; Pathology; Haplotype; Medicine; Biology; Disease; Genetics; Dementia; Gene; Allele","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003839841,0.0003837706,0.0003698688,0.001335484,0.0005380415,0.0003647856,0.0003093398,0.000469787,0.001655282],"category_scores_gemma":[0.001773399,0.0002034549,0.0002176156,0.0007178789,0.0004350892,0.0002519647,0.0003356695,0.0002402048,0.0003448818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003455758,"about_ca_system_score_gemma":0.0002605615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002052591,"about_ca_topic_score_gemma":0.001945896,"domain_scores_codex":[0.9996868,0.00004865268,0.00003940578,0.00008175655,0.00008719097,0.00005612709],"domain_scores_gemma":[0.9989734,0.0002145178,0.0004269162,0.00003858796,0.0001024645,0.0002441969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003178843,0.00005031933,0.9888601,0.00001347821,0.00004455572,0.00591824,0.0001300737,0.0001051857,0.002719462,0.00003505169,0.00008900507,0.001716665],"study_design_scores_gemma":[0.0000235286,0.0001533545,0.9744723,0.000008152022,0.00002433531,0.02436657,0.0001909003,0.0001726563,0.0004203179,0.00004205145,0.0001197632,0.000006162583],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999666,0.0000666013,0.00002433816,0.000009256826,0.000001250898,0.000003460406,0.00007606114,0.000001470204,0.0001516827],"genre_scores_gemma":[0.999649,0.00004036536,0.00007518492,0.00001344015,0.000006611754,0.000004768116,0.0001392182,0.000001451417,0.00006993584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002052591,"threshold_uncertainty_score":0.00553745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05126548121730867,"score_gpt":0.3157117583273418,"score_spread":0.2644462771100332,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}