{"id":"W2130071233","doi":"10.1001/archneurol.2011.53","title":"Genetic and Clinical Features of Progranulin-Associated Frontotemporal Lobar Degeneration","year":2011,"lang":"en","type":"article","venue":"Archives of Neurology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":121,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute on Aging; National Health and Medical Research Council; Medical Research Council; Canadian Institutes of Health Research; Arizona Biomedical Research Commission; Vlaamse regering; National Center for Research Resources; Fonds Wetenschappelijk Onderzoek; Deutsche Forschungsgemeinschaft; Belgian Federal Science Policy Office; Eusko Jaurlaritza; Arizona Department of Health Services; Wellcome Trust; National Institute of Neurological Disorders and Stroke; Bundesministerium für Bildung und Forschung; Bijzonder Onderzoeksfonds UGent; National Institutes of Health; Universiteit Antwerpen; U.S. Department of Veterans Affairs","keywords":"Frontotemporal lobar degeneration; Frontotemporal dementia; Mutation; Pathology; Haplotype; Medicine; Biology; Disease; Genetics; Dementia; Gene; Allele","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011621,0.00008379653,0.0003247671,0.00007407582,0.00002073715,0.000001666406,0.00009052063,0.00009946757,0.000031382],"category_scores_gemma":[0.0001816373,0.00006598204,0.0000845386,0.00005191231,0.0005472852,0.00002051621,0.00008165111,0.0002218519,0.000001529059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001816245,"about_ca_system_score_gemma":0.00004387467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002263074,"about_ca_topic_score_gemma":0.0001024661,"domain_scores_codex":[0.9988223,0.0002785556,0.0003666191,0.0002210665,0.0001278932,0.000183573],"domain_scores_gemma":[0.9993941,0.0001476609,0.0001314212,0.0001832715,0.00003974499,0.0001037716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001495159,0.0003688095,0.9502001,0.00003250685,0.00008245115,0.00003269274,0.000381786,8.210549e-7,0.02456317,0.0001232713,0.00008874217,0.02263053],"study_design_scores_gemma":[0.001290857,0.003656333,0.9929004,0.0000127044,0.00004475336,0.00002480591,0.000003246138,0.000277756,0.0009285192,0.0007798275,0.00003821944,0.00004255531],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977623,0.0002262765,0.00005054342,0.0004964044,0.00005054579,0.0002744101,0.000005371516,0.00001421368,0.001119938],"genre_scores_gemma":[0.9961036,0.0002900632,0.00327844,0.0001921754,0.00004711045,0.000005307825,0.000008716507,0.00001173255,0.00006288066],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04270035,"threshold_uncertainty_score":0.269067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05126548121730867,"score_gpt":0.3157117583273418,"score_spread":0.2644462771100332,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}