{"id":"W2130080665","doi":"10.1007/s00401-010-0751-5","title":"Molecular diagnostics of CNS embryonal tumors","year":2010,"lang":"en","type":"review","venue":"Acta Neuropathologica","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"National Institute of Neurological Disorders and Stroke","keywords":"Medulloblastoma; SMARCB1; Atypical teratoid rhabdoid tumor; Biology; PTCH1; Wnt signaling pathway; Primitive neuroectodermal tumor; Pathology; Cancer research; Brain tumor; Sonic hedgehog; Ependymoma; Immunohistochemistry; Genetics; Medicine; Gene; Epigenetics; Immunology; Chromatin remodeling","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001307397,0.001221581,0.001355087,0.002851375,0.00025094,0.0009882782,0.001577008,0.001664282,0.001575202],"category_scores_gemma":[0.001254363,0.0004459526,0.0004888081,0.001593909,0.001066806,0.001218523,0.0006619712,0.002313503,0.001486836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00126511,"about_ca_system_score_gemma":0.001156131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001530047,"about_ca_topic_score_gemma":0.00259346,"domain_scores_codex":[0.999707,0.00006210506,0.0000345039,0.00005210127,0.0001079144,0.00003624018],"domain_scores_gemma":[0.9992028,0.0004024729,0.000077089,0.00003715036,0.0002246688,0.00005585121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001181736,0.00008354455,0.0004252181,0.004947461,0.00007703343,0.0006703503,0.00004065917,0.0005613202,0.00577324,0.004623939,0.04243004,0.940249],"study_design_scores_gemma":[0.00004345217,0.0000654243,0.001460201,0.001691878,0.0001406927,0.004172429,0.00005266143,0.0002562841,0.003510921,0.003336274,0.985235,0.00003474994],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001425844,0.9973229,0.0006591963,0.000456455,0.000387149,0.000005656218,0.0000179513,0.00001330499,0.0009948044],"genre_scores_gemma":[0.001641113,0.9951649,0.001106514,0.0003897996,0.0005150215,0.00001231924,0.00005583156,0.000003301977,0.001111165],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002851375,"threshold_uncertainty_score":0.009179056,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0239187628210248,"score_gpt":0.3017264177768105,"score_spread":0.2778076549557857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}