{"id":"W2130082562","doi":"10.1136/annrheumdis-2013-204963","title":"Sarilumab for the treatment of ankylosing spondylitis: results of a Phase II, randomised, double-blind, placebo-controlled study (ALIGN)","year":2014,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":152,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital","funders":"Regeneron Pharmaceuticals; Sanofi","keywords":"Medicine; Adverse effect; Placebo; Internal medicine; Clinical endpoint; Ankylosing spondylitis; Neutropenia; Randomized controlled trial; Toxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005537164,0.0002765632,0.001432247,0.00009162677,0.0002649658,0.00001274212,0.0001970316,0.00003839057,0.00004279503],"category_scores_gemma":[0.000870206,0.000134641,0.0008955579,0.0001795229,0.0002118987,0.00005415785,0.00005425057,0.00003106642,0.000001011549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002330786,"about_ca_system_score_gemma":0.00009036512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003573884,"about_ca_topic_score_gemma":0.00004777814,"domain_scores_codex":[0.9977608,0.0001813155,0.001084231,0.0002548344,0.0004411873,0.0002776207],"domain_scores_gemma":[0.9962,0.001749561,0.0007999411,0.0008326026,0.0003148836,0.0001029938],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9164596,0.0218568,0.0008038869,0.0002954403,0.006636297,0.000003900606,0.003405348,0.00004595512,0.00004118353,0.0002004195,0.0009342642,0.04931697],"study_design_scores_gemma":[0.9712882,0.01518869,0.002080063,0.0009878949,0.004699674,0.000004920598,0.001974872,0.0005836475,0.001968669,0.0003650533,0.0007235521,0.0001347788],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820173,0.006634942,0.00002706492,0.0009856104,0.0001813483,0.008858321,0.0009402061,0.00001698306,0.0003382163],"genre_scores_gemma":[0.9972339,0.001136065,0.00004550672,0.00004929785,0.00004894899,0.001000603,0.00005422331,0.00002321882,0.000408287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05482865,"threshold_uncertainty_score":0.5490501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06819954645693337,"score_gpt":0.3656415064500914,"score_spread":0.297441959993158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}