{"id":"W2130112316","doi":"10.1093/jnci/djs139","title":"CYP2D6 Genotype as a Marker for Benefit of Adjuvant Tamoxifen in Postmenopausal Women: Lessons Learned","year":2012,"lang":"en","type":"letter","venue":"JNCI Journal of the National Cancer Institute","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sunnybrook Health Science Centre","funders":"","keywords":"Tamoxifen; Genotype; Postmenopausal women; Medicine; Oncology; Adjuvant; Internal medicine; Antiestrogen; Gynecology; Breast cancer; Cancer; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005215043,0.0002284263,0.0003715663,0.000149429,0.00006827648,0.0000143913,0.0004719855,0.0006502144,0.0000308557],"category_scores_gemma":[0.0002167759,0.0001595567,0.0002585452,0.0001338647,0.0001162768,0.00001675259,0.0001014583,0.0008595242,0.000002806512],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003234582,"about_ca_system_score_gemma":0.0011472,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003484609,"about_ca_topic_score_gemma":0.0000210765,"domain_scores_codex":[0.9983521,0.0000700716,0.0005079304,0.0001903054,0.0005592197,0.000320394],"domain_scores_gemma":[0.9983816,0.00004359126,0.0007735512,0.0001527548,0.0005831968,0.00006527911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00341093,0.0003182992,0.001129805,0.0004348083,0.002600294,0.00006513682,0.0004192217,0.004740647,0.3037798,0.0006081071,0.6763573,0.006135605],"study_design_scores_gemma":[0.001732451,0.0005605904,0.001798671,0.0002341483,0.0001599123,0.0001992726,0.000009827264,0.00001342481,0.01898357,0.001533475,0.9744917,0.0002829763],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7858926,0.01554936,0.00003988425,0.1896837,0.005708016,0.0008446724,0.0008012712,0.000004703677,0.001475807],"genre_scores_gemma":[0.8150735,0.003509045,0.0006926261,0.1543846,0.01770226,0.0002022296,0.0004092804,0.0001423651,0.007884078],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2981344,"threshold_uncertainty_score":0.6506534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03624090210001409,"score_gpt":0.3346795941000729,"score_spread":0.2984386920000588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}