{"id":"W2130132011","doi":"10.1128/jvi.00293-08","title":"A Glycoconjugate Antigen Based on the Recognition Motif of a Broadly Neutralizing Human Immunodeficiency Virus Antibody, 2G12, Is Immunogenic but Elicits Antibodies Unable To Bind to the Self Glycans of gp120","year":2008,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; International AIDS Vaccine Initiative","keywords":"Immunogen; Biology; Glycan; Antibody; Epitope; Virology; Neutralizing antibody; Immunoglobulin Fab Fragments; Antigen; Complementarity determining region; Biochemistry; Virus; Glycoprotein; Monoclonal antibody; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008636931,0.0002525134,0.0006275365,0.0004428019,0.0005241811,0.00001300873,0.0006531893,0.0001909853,0.000378547],"category_scores_gemma":[0.0001505841,0.0001487826,0.0003157291,0.0004190259,0.0003695795,0.00008539683,0.0001167668,0.0004985051,0.000300161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006466635,"about_ca_system_score_gemma":0.0002464979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009173528,"about_ca_topic_score_gemma":0.00006673822,"domain_scores_codex":[0.997497,0.0006436112,0.0008561049,0.0002518647,0.0001690955,0.0005823091],"domain_scores_gemma":[0.9981462,0.0003677045,0.0005597231,0.0004822976,0.0003865684,0.00005754557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001439126,0.0007131503,0.003650764,0.00001682594,0.0005767154,0.00005654339,0.002406287,0.0001827572,0.9889382,0.00004604419,0.001144027,0.0008295802],"study_design_scores_gemma":[0.003095367,0.008768362,0.1063498,0.0001615359,0.0001650327,0.0006385458,0.0005356814,0.00001939242,0.8735793,0.000102796,0.006358599,0.0002255921],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993876,0.001943865,0.000114539,0.002737823,0.0002241439,0.0005253594,0.0002133416,0.00001161778,0.0003532822],"genre_scores_gemma":[0.9978442,0.00102346,0.0001262837,0.0007754178,0.00003457075,0.000013404,0.00002730709,0.00002084379,0.0001345299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1153589,"threshold_uncertainty_score":0.6067179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03397746029108308,"score_gpt":0.2932032781027943,"score_spread":0.2592258178117113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}