{"id":"W2130132011","doi":"10.1128/jvi.00293-08","title":"A Glycoconjugate Antigen Based on the Recognition Motif of a Broadly Neutralizing Human Immunodeficiency Virus Antibody, 2G12, Is Immunogenic but Elicits Antibodies Unable To Bind to the Self Glycans of gp120","year":2008,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; International AIDS Vaccine Initiative","keywords":"Immunogen; Biology; Glycan; Antibody; Epitope; Virology; Neutralizing antibody; Immunoglobulin Fab Fragments; Antigen; Complementarity determining region; Biochemistry; Virus; Glycoprotein; Monoclonal antibody; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009955292,0.0006234995,0.0002246816,0.000204366,0.00008562056,0.0002139008,0.0002091109,0.0003845994,0.0003908369],"category_scores_gemma":[0.00009465089,0.0001364636,0.0002448747,0.0001755121,0.0002246137,0.0001345394,0.0002227033,0.0005121244,0.0001744829],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003119352,"about_ca_system_score_gemma":0.0001452548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003205583,"about_ca_topic_score_gemma":0.0005326374,"domain_scores_codex":[0.9998767,0.00002520842,0.000006906831,0.00002021973,0.00004216353,0.00002873913],"domain_scores_gemma":[0.9999336,0.000008899373,0.00002373737,0.000007869428,0.000006727293,0.0000192791],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003285043,0.00003219944,0.0001383356,0.00001356103,0.000003641314,0.00002469238,0.000004048237,0.00006999649,0.9984266,0.00004561557,0.00001268568,0.001195795],"study_design_scores_gemma":[0.0000196562,0.001066139,0.003739108,0.000004804965,0.00001890015,0.0006423258,0.000008570811,0.0005978032,0.9916962,0.00003200219,0.002170031,0.000004494264],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942657,0.0006135923,0.003905903,0.00005584717,0.00002012977,0.00006027288,0.00009527733,0.00005984326,0.0009234661],"genre_scores_gemma":[0.9901292,0.000659904,0.007207716,0.00009317399,0.0000117908,0.00003197457,0.0003701441,0.00001304342,0.001483045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006234995,"threshold_uncertainty_score":0.002263308,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03397746029108308,"score_gpt":0.2932032781027943,"score_spread":0.2592258178117113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}