{"id":"W2130164418","doi":"10.1634/theoncologist.2015-0220","title":"Temsirolimus Maintenance Therapy After Docetaxel Induction in Castration-Resistant Prostate Cancer","year":2015,"lang":"en","type":"article","venue":"The Oncologist","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; London Health Sciences Centre; Queen's University; Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Docetaxel; Prostate cancer; Temsirolimus; Oncology; Castration; Internal medicine; Cancer; Discovery and development of mTOR inhibitors; Apoptosis; PI3K/AKT/mTOR pathway; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007488892,0.000192613,0.0007056224,0.0001498987,0.0001121577,0.0003581301,0.0003516846,0.0002955947,0.0004389918],"category_scores_gemma":[0.0005370101,0.00007163038,0.0003368335,0.0002171496,0.0003110942,0.0002622531,0.000120988,0.000996676,0.00008325506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003667437,"about_ca_system_score_gemma":0.000540762,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004405176,"about_ca_topic_score_gemma":0.001348033,"domain_scores_codex":[0.9997929,0.00009179278,0.00001791455,0.00002753807,0.00003000983,0.00003991529],"domain_scores_gemma":[0.9997655,0.00006732113,0.00006886302,0.00002397602,0.0000160986,0.00005821855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.0595669,0.008484567,0.02535389,0.001268597,0.0006905123,0.000679997,0.0003488424,0.004449026,0.09081649,0.0005732932,0.00389492,0.8038729],"study_design_scores_gemma":[0.06534605,0.6061954,0.2393322,0.0004203113,0.00123977,0.00430651,0.0002400585,0.01015022,0.04602234,0.001152442,0.02549146,0.0001032092],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862096,0.01200069,0.0004881844,0.0004808411,0.00005329473,0.0001128102,0.00005438465,0.00003534802,0.0005648811],"genre_scores_gemma":[0.9952898,0.003181619,0.0006674444,0.0002843155,0.0000891715,0.00009415271,0.0001069816,0.000004760053,0.0002816951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007488892,"threshold_uncertainty_score":0.00396055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09766706703691744,"score_gpt":0.3809797610678705,"score_spread":0.283312694030953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}