{"id":"W2130190973","doi":"10.3389/fgene.2014.00245","title":"Turnover of protein phosphorylation evolving under stabilizing selection","year":2014,"lang":"en","type":"review","venue":"Frontiers in Genetics","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Genome Canada; University of Toronto; Université Laval; PROTEO","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Phosphorylation; Selection (genetic algorithm); Protein phosphorylation; Protein stability; Biology; Computational biology; Cell biology; Genetics; Computer science; Protein kinase A; Artificial intelligence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002798896,0.0002544078,0.000620026,0.0001622922,0.00002406552,0.00001279893,0.0001468956,0.0004246245,0.000004795803],"category_scores_gemma":[0.00007577239,0.0002483384,0.0001676286,0.0002589943,0.00003966883,0.000002379289,0.00004910967,0.0001895941,0.000001307899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006478444,"about_ca_system_score_gemma":0.0001113711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007545471,"about_ca_topic_score_gemma":0.000007732393,"domain_scores_codex":[0.9987175,0.00009836695,0.0004785087,0.0003937073,0.0001103479,0.0002015268],"domain_scores_gemma":[0.9993322,0.000002240625,0.0002628105,0.0002924512,0.00007784075,0.0000324732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001852204,0.00007505588,0.0002209425,0.009014029,0.000188464,2.302689e-7,0.00002962776,0.00214768,0.06832284,0.00002017274,0.002374799,0.9175876],"study_design_scores_gemma":[0.0001482348,0.00009112881,0.00003788295,0.001483765,0.0001339814,0.000005740848,0.00001024906,0.0001926729,0.01733062,0.00002765542,0.980211,0.0003270417],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001696532,0.9622635,0.0346042,0.00000228837,0.000856235,0.0005143753,0.000009144033,0.00001022607,0.00004346814],"genre_scores_gemma":[0.002926175,0.979256,0.01680098,0.000003678857,0.0004895532,0.00003391008,0.0001330735,0.00005761874,0.0002990532],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9778363,"threshold_uncertainty_score":0.9999969,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01083425447955329,"score_gpt":0.252108045068285,"score_spread":0.2412737905887317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}