{"id":"W2130200708","doi":"10.1042/bj20121403","title":"Kinetic analysis of <i>Arabidopsis</i> glucosyltransferase UGT74B1 illustrates a general mechanism by which enzymes can escape product inhibition","year":2012,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Leibniz-Institut für Pflanzenbiochemie","keywords":"Product inhibition; Biochemistry; Mutant; Arabidopsis; Enzyme; Serine; Enzyme kinetics; Biology; Glycosyltransferase; Biosynthesis; Chemistry; Stereochemistry; Active site; Gene; Non-competitive inhibition","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003055564,0.0003224893,0.0004408087,0.000150347,0.00009417655,0.00004145033,0.0002547698,0.000237768,0.00009233699],"category_scores_gemma":[0.0001342513,0.0002957,0.000339721,0.0004850877,0.0001371187,0.00001360063,0.00007690378,0.0002798653,0.00000277688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004135559,"about_ca_system_score_gemma":0.00008876616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002337103,"about_ca_topic_score_gemma":0.00001288243,"domain_scores_codex":[0.9980065,0.0001145351,0.0005782201,0.0004229767,0.0003013456,0.0005764063],"domain_scores_gemma":[0.9986781,0.00001661323,0.0002383767,0.0003408272,0.0003362798,0.000389783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001039798,0.0003373017,0.001903251,0.00002449719,0.0006529395,0.000001154161,0.0000883229,0.00002218759,0.9912131,0.00009256201,0.005368864,0.0001917826],"study_design_scores_gemma":[0.0006047951,0.0001545406,0.0008038852,0.00001917283,0.0005707309,0.000051723,0.00008595278,0.00003713835,0.9962763,0.0001186525,0.0009272138,0.0003498649],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928719,0.004545643,0.001592645,0.0002389468,0.0001723564,0.0001576753,0.0002851191,0.0000105021,0.0001252257],"genre_scores_gemma":[0.9958963,0.0007319568,0.001231838,0.0002109433,0.0009486801,0.00001486673,0.0008512218,0.0000330231,0.00008121916],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005063173,"threshold_uncertainty_score":0.9999495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007705642388442651,"score_gpt":0.2285161409747542,"score_spread":0.2208104985863115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}