{"id":"W2130200708","doi":"10.1042/bj20121403","title":"Kinetic analysis of <i>Arabidopsis</i> glucosyltransferase UGT74B1 illustrates a general mechanism by which enzymes can escape product inhibition","year":2012,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Leibniz-Institut für Pflanzenbiochemie","keywords":"Product inhibition; Biochemistry; Mutant; Arabidopsis; Enzyme; Serine; Enzyme kinetics; Biology; Glycosyltransferase; Biosynthesis; Chemistry; Stereochemistry; Active site; Gene; Non-competitive inhibition","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001532755,0.0005296983,0.0003195982,0.0002697372,0.0001137303,0.0003326671,0.0002948056,0.0002614247,0.001001365],"category_scores_gemma":[0.0002940446,0.0001801264,0.0004084033,0.0003299296,0.0001463891,0.0002173765,0.00007905417,0.0006025657,0.0006025855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008648117,"about_ca_system_score_gemma":0.0002815559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006973004,"about_ca_topic_score_gemma":0.003026084,"domain_scores_codex":[0.9998621,0.00001231721,0.000008874363,0.00004443737,0.00004646593,0.0000258086],"domain_scores_gemma":[0.9998509,0.00003665456,0.00004347507,0.00001712573,0.00003466025,0.00001714279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001675409,0.00003497866,0.002475023,0.0000745813,0.00003166907,0.0000652882,0.0000216396,0.002177962,0.9898688,0.0004026528,0.0001757708,0.004504221],"study_design_scores_gemma":[0.00000724848,0.0001199103,0.008991476,0.000004259992,0.00002301011,0.0001354588,0.0000159892,0.02404907,0.9649042,0.0001509308,0.00157701,0.00002150254],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9614047,0.001220893,0.03099937,0.0001586594,0.00002778272,0.00003587388,0.00258705,0.0006714275,0.002894239],"genre_scores_gemma":[0.9883364,0.0005376108,0.007095356,0.00002599675,0.000003400036,0.00002397675,0.002183087,0.00009953281,0.001694567],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006973004,"threshold_uncertainty_score":0.01386482,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007705642388442651,"score_gpt":0.2285161409747542,"score_spread":0.2208104985863115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}